多发性骨髓瘤和急性髓系白血病中CAR-T细胞的新型靶点与技术 - Suppr

Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia.

作者信息

Prommersberger Sabrina, Jetani Hardikkumar, Danhof Sophia, Monjezi Razieh, Nerreter Thomas, Beckmann Julia, Einsele Herrmann, Hudecek Michael

机构信息

Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.

出版信息

Curr Res Transl Med. 2018 May;66(2):37-38. doi: 10.1016/j.retram.2018.03.006. Epub 2018 Apr 11.

DOI:10.1016/j.retram.2018.03.006

PMID:29655962

Abstract

摘要

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Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia.多发性骨髓瘤和急性髓系白血病中CAR-T细胞的新型靶点与技术

Curr Res Transl Med. 2018 May;66(2):37-38. doi: 10.1016/j.retram.2018.03.006. Epub 2018 Apr 11.

CAR T-cells targeting FLT3 have potent activity against FLT3ITD AML and act synergistically with the FLT3-inhibitor crenolanib.嵌合抗原受体 T 细胞（CAR T-cells）针对 FLT3 的治疗在伴有 FLT3-ITD 的 AML 中具有显著疗效，与 FLT3 抑制剂 crenolanib 有协同作用。

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CAR T-cells: A John von Neumann legacy?嵌合抗原受体T细胞：约翰·冯·诺依曼的遗产？

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CAR T-cell therapy against B-cell maturation antigen in multiple myeloma.用于治疗多发性骨髓瘤的靶向B细胞成熟抗原的嵌合抗原受体T细胞疗法

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Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery.带有关闭开关的同种异体 FLT3 CAR T 细胞对 AML 具有强大的活性，并可被清除以加速骨髓恢复。

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Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor-Redirected T Cells Against Multiple Myeloma.来那度胺增强 CS1 嵌合抗原受体修饰 T 细胞对多发性骨髓瘤的功能。

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Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7.表达自杀基因和靶向信号淋巴细胞激活分子 F7 的嵌合抗原受体的 CAR T 细胞的开发。

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Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization.对嵌合抗原受体胞外结构域激活的研究：靶向多发性骨髓瘤细胞的单域抗体的经验突出了需要针对具体情况进行优化。

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SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7 normal lymphocytes.SLAMF7-CAR T 细胞可消除骨髓瘤并选择性杀伤 SLAMF7 正常淋巴细胞。

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Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia.

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