Gleeson Molly D, Moore Bret A, Edwards Sydney G, Stevens Sarah, Childress April L, Wellehan James F X, Robertson Jessica, Murphy Christopher J, Hawkins Michelle G, Paul-Murphy Joanne
School of Veterinary Medicine, William R. Pritchard Veterinary Medical Teaching Hospital, University of California-Davis, Davis, CA, USA.
Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Vet Ophthalmol. 2019 Jan;22(1):67-75. doi: 10.1111/vop.12570. Epub 2018 Apr 14.
An adult great-horned owl (Bubo virginianus; GHOW) presented with a history of recurrent corneal ulceration of the right eye (OD). Findings included ulcerative superficial keratitis, proliferative conjunctivitis, and iris pigmentary changes. The ulcer was initially nonresponsive to medical therapy, but showed rapid and appropriate healing following diamond burr debridement. Proliferative conjunctivitis markedly improved following topical antiviral therapy with cidofovir 1%, interferon alpha 2B ophthalmic solutions, and oral l-lysine. Histopathologic evaluation of a conjunctival biopsy revealed epithelial features suspicious for viral cytopathic changes and intranuclear structures suspicious for viral inclusions, suggestive of a possible viral-induced papillomatous conjunctivitis. A novel alphaherpesvirus, referred to as Strigid Herpesvirus 1 (StrHV1), was identified using PCR and gene sequencing. This case represents a new clinical manifestation of a previously unreported herpesvirus in the GHOW. Identification of the herpes virus was critical to administration of appropriate therapy and resolution of the conjunctivitis, and corneal epithelial debridement promoted resolution of the chronic corneal epithelial defect.
一只成年大角鸮（Bubo virginianus；GHOW）右眼（OD）有复发性角膜溃疡病史。检查发现包括溃疡性浅层角膜炎、增殖性结膜炎和虹膜色素变化。该溃疡最初对药物治疗无反应，但在钻石磨盘清创术后迅速且顺利愈合。在用1%西多福韦、干扰素α 2B眼药水局部抗病毒治疗及口服L-赖氨酸后，增殖性结膜炎明显改善。结膜活检的组织病理学评估显示上皮特征可疑为病毒细胞病变变化，核内结构可疑为病毒包涵体，提示可能为病毒诱导的乳头瘤性结膜炎。使用聚合酶链反应（PCR）和基因测序鉴定出一种新型α疱疹病毒，称为鸮疱疹病毒1（StrHV1）。该病例代表了GHOW中一种先前未报道的疱疹病毒的新临床表现。疱疹病毒的鉴定对于给予适当治疗和结膜炎的消退至关重要，角膜上皮清创促进了慢性角膜上皮缺损的消退。
