Bozlu Gulcin, Karpuz Derya, Hallioglu Olgu, Unal Selma, Kuyucu Necdet
1Department of Pediatrics,University of Mersin Faculty of Medicine,Mersin,Turkey.
Cardiol Young. 2018 Jun;28(6):832-836. doi: 10.1017/S1047951118000422. Epub 2018 Apr 16.
Recently, mean platelet volume-to-lymphocyte ratio has emerged as a novel parameter of inflammation. No study has investigated the role of mean platelet volume-to-lymphocyte ratio in children with Kawasaki disease. We aimed to evaluate the relationship between mean platelet volume-to-lymphocyte ratio and coronary artery abnormalities in Kawasaki disease.
Between January 2008 and January 2017, a total of 58 children with Kawasaki disease and 42 healthy subjects matched for sex and age were enrolled. Before the treatment, transthoracic echocardiography for all children was performed. Clinical and laboratory results including mean platelet volume, platelet distribution width, red blood cell distribution width, and counts of platelets, neutrophils, lymphocytes, and white blood cells, erythrocyte sedimentation rate, and C-reactive protein levels were measured. Mean platelet volume-to-lymphocyte ratio was calculated as mean platelet volume divided by lymphocyte count.
Compared with healthy controls, mean platelet volume-to-lymphocyte ratio was significantly lower in the children with Kawasaki disease (p<0.01). A total of 14 patients (24.1%) had incomplete Kawasaki disease and 15 (25.8%) children with Kawasaki disease had coronary involvement. Mean platelet volume-to-lymphocyte ratio was significantly lower in patients with coronary artery abnormalities (p<0.01). According to receiver operating characteristic curve analysis performed for the prediction of coronary artery abnormalities, the best cut-off point for mean platelet volume-to-lymphocyte ratio was 2.5 (area under curve=0.593, sensitivity 53.3%, specificity 51.1%).
It was first shown that the children with Kawasaki disease have lower mean platelet volume-to-lymphocyte ratio compared with control subjects. Mean platelet volume-to-lymphocyte ratio may be helpful in predicting coronary artery lesions in patients with Kawasaki disease.
近期，平均血小板体积与淋巴细胞比值已成为一种新的炎症参数。尚无研究探讨平均血小板体积与淋巴细胞比值在川崎病患儿中的作用。我们旨在评估川崎病患儿平均血小板体积与淋巴细胞比值与冠状动脉异常之间的关系。
2008年1月至2017年1月，共纳入58例川崎病患儿及42例年龄和性别相匹配的健康对照。治疗前，对所有患儿进行经胸超声心动图检查。测量临床和实验室结果，包括平均血小板体积、血小板分布宽度、红细胞分布宽度、血小板、中性粒细胞、淋巴细胞和白细胞计数、红细胞沉降率及C反应蛋白水平。平均血小板体积与淋巴细胞比值计算为平均血小板体积除以淋巴细胞计数。
与健康对照组相比，川崎病患儿的平均血小板体积与淋巴细胞比值显著降低（p<0.01）。共有14例患者（24.1%）患不完全川崎病，15例（25.8%）川崎病患儿有冠状动脉受累。冠状动脉异常患者的平均血小板体积与淋巴细胞比值显著降低（p<0.01）。根据用于预测冠状动脉异常的受试者工作特征曲线分析，平均血小板体积与淋巴细胞比值的最佳截断点为2.5（曲线下面积=0.593，敏感性53.3%，特异性51.1%）。
首次表明川崎病患儿的平均血小板体积与淋巴细胞比值低于对照组。平均血小板体积与淋巴细胞比值可能有助于预测川崎病患者的冠状动脉病变。
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