Department of Cardiovascular Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China.
Eur J Pediatr. 2021 Jul;180(7):2253-2259. doi: 10.1007/s00431-021-03977-5. Epub 2021 Mar 13.
Kawasaki disease (KD) is an acute systemic vasculitis in children. Coronary artery lesions (CALs) are the most serious complications in KD, but the pathogenesis is still unclear so far. Adropin, a new biopeptide, plays an important role in metabolism and cardiovascular function. The aim of this study was to explore the relationship between adropin and KD. 66 KD patients and 22 healthy controls (HCs) were included in the study. KD patients were divided into KD with coronary artery lesions (KD-CALs) group and KD without CALs (KD-NCALs) group. The levels of serum adropin were determined by enzyme-linked immunosorbent assay (ELISA). Compared with the HC group, adropin concentrations were significantly increased in the KD group (p < 0.05), and the KD-CAL group had higher levels of adropin than those in the KD-NCAL group (p < 0.05). Pct (Procalcitonin) and DD (D-dimer) were positively correlated with adropin in the KD group (p < 0.05). Moreover, adropin had positive correlations with CRP (C-reactive protein) and DD in the KD-NCAL group and positive correlations with Pct, PLR (platelet-to-lymphocyte ratio), and DD in the KD-CAL group (p < 0.05). The receiver operating characteristic (ROC) curve showed that the best threshold value of serum adropin level was more than 2.8 ng/mL, with 72.2% sensitivity and 71.4% specificity for predicting CALs in children with KD.Conclusion: Adropin might be involved in the pathogenesis of KD and CALs and can be used as an auxiliary diagnostic biomarker of KD. What is Known: • CALs in KD were mainly caused by inflammation, immune imbalance, and vascular endothelial dysfunction, and adropin is involved in metabolic diseases and cardiovascular diseases. What is New: • In this study, we have found the relationship between adropin and KD, and serum adropin level can be used as an auxiliary diagnostic biomarker to predict CALs in KD.
川崎病（KD）是儿童期的一种急性全身性血管炎。冠状动脉病变（CALs）是 KD 最严重的并发症，但迄今为止其发病机制仍不清楚。阿多品是一种新的生物肽，在代谢和心血管功能中发挥着重要作用。本研究旨在探讨阿多品与 KD 的关系。研究纳入 66 例 KD 患儿和 22 例健康对照者（HCs）。KD 患儿分为合并冠状动脉病变（KD-CALs）组和不合并冠状动脉病变（KD-NCALs）组。采用酶联免疫吸附法（ELISA）测定血清阿多品水平。与 HCs 组相比，KD 组阿多品浓度显著升高（p＜0.05），KD-CALs 组阿多品水平高于 KD-NCALs 组（p＜0.05）。降钙素原（Pct）和 D-二聚体（DD）与 KD 组阿多品呈正相关（p＜0.05）。此外，KD-NCALs 组阿多品与 CRP（C 反应蛋白）和 DD 呈正相关，KD-CALs 组阿多品与 PCT、PLR（血小板与淋巴细胞比值）和 DD 呈正相关（p＜0.05）。ROC 曲线显示，血清阿多品水平最佳截断值大于 2.8ng/ml，对预测 KD 患儿 CALs 的灵敏度为 72.2%，特异度为 71.4%。结论：阿多品可能参与 KD 及 CALs 的发病机制，可作为 KD 的辅助诊断生物标志物。已知：• KD 中的 CALs 主要由炎症、免疫失衡和血管内皮功能障碍引起，阿多品参与代谢性疾病和心血管疾病。新发现：• 本研究发现了阿多品与 KD 之间的关系，血清阿多品水平可作为辅助诊断标志物，预测 KD 中的 CALs。
