Department of Cardiovascular Medicine, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
Mediators Inflamm. 2021 Jan 11;2021:7029514. doi: 10.1155/2021/7029514. eCollection 2021.
Kawasaki disease (KD) is a self-limited vasculitis with unknown etiologies, and coronary artery lesions (CALs) are the most common and serious complications. Retinol-binding protein 4 (RBP4) has been confirmed effects on vasodilation, platelet activation inhibition, and cardiovascular diseases by researches. Therefore, this study was aimed at investigating the relationship between RBP4 and inflammation as well as thrombogenesis in children with KD.
79 subjects were from 62 children with KD and 17 healthy controls (HCs). The KD group was divided into KD with CALs (KD-CALs) and KD without CALs (KD-NCALs), and the serum RBP4 levels were measured by enzyme-linked immunosorbent assay (ELISA).
Compared with the HC group, serum RBP4 levels in the KD group were significantly decreased ( < 0.05). RBP4, hemoglobin (Hb), and mean platelet volume (MPV) levels were higher, while platelet counts (Plt) and thrombin time (TT) levels were lower in the KD-NCALs group than in the KD-CALs group ( < 0.05). RBP4 had positive correlation with time point of intravenous immunoglobulin (IVIG), Hb, and percentage of leukomonocytes (L%) and negative correlation with the percentage of neutrophils (N%), MPV, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), fibrinogen (Fbg), and D-dimer (DD) in the KD group; RBP4 had positive correlation with the time point of IVIG and L% and negative correlation with N%, MPV, and NLR in the KD-NCALs group; and RBP4 had positive correlation with Hb and L% and negative correlation with N%, CRP, NLR, and PT in the KD-CALs group ( < 0.05). Multiple linear regression analysis confirmed that Hb and CRP in the KD group, MPV and N% in the KD-NCALs group, and PT and CRP in the KD-CALs group were independent predictors of RBP4 ( < 0.05).
Lower RBP4 was observed in the KD group than in the HC group, and RBP4 had associations with markers of inflammation and thrombogenesis in children with KD.
川崎病（KD）是一种病因不明的自限性血管炎，冠状动脉病变（CALs）是最常见和最严重的并发症。研究证实，视黄醇结合蛋白 4（RBP4）对血管舒张、血小板活化抑制和心血管疾病有影响。因此，本研究旨在探讨 RBP4 与川崎病患儿炎症和血栓形成的关系。
79 例患者来自 62 例川崎病患儿和 17 例健康对照者（HCs）。KD 组分为川崎病伴 CALs（KD-CALs）和川崎病无 CALs（KD-NCALs），采用酶联免疫吸附试验（ELISA）检测血清 RBP4 水平。
与 HC 组相比，KD 组血清 RBP4 水平明显降低（<0.05）。KD-NCALs 组 RBP4、血红蛋白（Hb）和平均血小板体积（MPV）水平较高，血小板计数（Plt）和凝血酶时间（TT）水平较低，而 KD-CALs 组与 KD-NCALs 组比较差异有统计学意义（<0.05）。KD 组 RBP4 与静脉注射免疫球蛋白（IVIG）时间点、Hb 和白细胞单核细胞百分比（L%）呈正相关，与中性粒细胞百分比（N%）、MPV、C 反应蛋白（CRP）、中性粒细胞与淋巴细胞比值（NLR）、凝血酶原时间（PT）、纤维蛋白原（Fbg）和 D-二聚体（DD）呈负相关；KD-NCALs 组 RBP4 与 IVIG 时间点和 L%呈正相关，与 N%、MPV 和 NLR 呈负相关；KD-CALs 组 RBP4 与 Hb 和 L%呈正相关，与 N%、CRP、NLR 和 PT 呈负相关（<0.05）。多元线性回归分析证实，KD 组的 Hb 和 CRP、KD-NCALs 组的 MPV 和 N%以及 KD-CALs 组的 PT 和 CRP 是 RBP4 的独立预测因子（<0.05）。
KD 组血清 RBP4 水平低于 HC 组，RBP4 与川崎病患儿炎症和血栓形成标志物有关。
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