Roessingh Research and Development, Telemedicine group, Roessinghsbleekweg 33b, 7522 AH Enschede, The Netherlands; Faculty of Electrical Engineering, Mathematics and Computer Science, Telemedicine group, University of Twente, Postbox 217, 7500 AE Enschede, The Netherlands; ZGT Academy, Ziekenhuis Groep Twente, Zilvermeeuw 1, 7609 PP Almelo, The Netherlands.
Roessingh Research and Development, Telemedicine group, Roessinghsbleekweg 33b, 7522 AH Enschede, The Netherlands.
Lung Cancer. 2018 May;119:91-98. doi: 10.1016/j.lungcan.2018.03.006. Epub 2018 Mar 9.
Our objectives were to 1) characterize daily physical behavior of operable non-small cell lung cancer (NSCLC) patients, from preoperative to six months postoperative using accelerometry, and explore if physical behavior preoperative or one month postoperative is associated with better health outcomes at six months postoperative.
A prospective study with 23 patients (13 female) diagnosed with primary NSCLC and scheduled for curative lung resection was performed. Outcome measures were assessed two weeks preoperative, and one, three and six months postoperative, and included accelerometer-derived physical behavior measures and the following health outcomes: six minute walking distance (6MWD), questionnaires concerning health-related quality of life (HRQOL), fatigue and distress.
On group average, physical behavior showed significant changes over time. Physical behavior worsened following surgery, but improved between one and six months postoperative, almost reaching preoperative levels. However, physical behavior showed high variability between patients in both amount as well as change over time. More time in moderate-to-vigorous physical activity in bouts of 10 min or longer in the first month postoperative was significantly associated with better 6MWD, HRQOL, distress, and fatigue at six months postoperative.
As expected, curative lung resection impacts physical behavior. Patients who were more active in the first month following surgery reported better health outcome six months postoperative. The large variability in activity patterns over time observed between patients, suggests that physical behavior 'profiling' through detailed monitoring of physical behavior could facilitate tailored goal setting in interventions that target change in physical behavior.
我们的目的是 1）使用加速度计描述可手术非小细胞肺癌（NSCLC）患者从术前到术后 6 个月的日常身体活动，并探讨术前或术后 1 个月的身体活动是否与术后 6 个月的更好健康结果相关。
对 23 例（13 名女性）诊断为原发性 NSCLC 并计划进行根治性肺切除术的患者进行了前瞻性研究。在术前两周、术后 1、3 和 6 个月评估了结局指标，包括加速度计得出的身体活动测量值以及以下健康结果：6 分钟步行距离（6MWD）、健康相关生活质量（HRQOL）、疲劳和困扰问卷。
总体而言，身体行为随时间发生了显著变化。手术后身体行为恶化，但在 1 至 6 个月时逐渐改善，几乎恢复到术前水平。然而，患者之间的身体行为在数量和随时间的变化方面存在很大的差异。术后第一个月，中高强度身体活动时间更长（每次 10 分钟或更长时间）的患者，6MWD、HRQOL、困扰和疲劳的结果在术后 6 个月时明显更好。
正如预期的那样，根治性肺切除术会影响身体行为。术后第一个月更活跃的患者报告说术后 6 个月的健康结果更好。患者之间随时间观察到的活动模式的巨大差异表明，通过详细监测身体活动进行身体行为“分析”可以促进针对身体行为改变的干预措施中的目标设定。
