Faculty of Health Disciplines, Athabasca University, Athabasca, Canada.
Centre for Health Services Research, The University of Queensland, Brisbane, Australia.
Lung Cancer. 2018 May;119:78-84. doi: 10.1016/j.lungcan.2018.03.010. Epub 2018 Mar 10.
No studies have examined objectively assessed physical activity, sedentary time, and patient-reported outcomes among lung cancer survivors. The objective of this study was to determine associations of objectively assessed moderate-to-vigorous intensity physical activity (MVPA) and sedentary time with health-related quality of life (HRQoL) and fatigue among lung cancer survivors.
Lung cancer survivors in Southern Alberta (N = 540) were invited to complete a mailed survey that assessed HRQoL [Functional Assessment of Cancer Therapy-Lung (FACT-L)], physical and functional well-being [Trial Outcome Index (TOI)], and fatigue [Fatigue Scale (FS)]. Physical activity and sedentary time data was collected using an Actigraph GT3X+ accelerometer that was worn on the hip for seven consecutive days. Quantile regression was used to examine associations of HRQoL and fatigue with physical activity and sedentary time at the 25th, 50th, and 75th HRQoL and fatigue percentiles.
A total of 127 lung cancer survivors participated for a 24% response rate (Mean age = 71 years; Mean time since diagnosis = 75 months). Total MVPA minutes was positively associated with fewer fatigue symptoms at the 25th percentile (β = 0.16, p = 0.046). Total sedentary time was inversely associated with HRQoL at the 75th percentile (β = -0.07, p = 0.014) and inversely associated with fatigue symptoms at the 50th percentile (β = -0.04, p = 0.009). Total sedentary time was also inversely associated with physical and functional well-being scores at the 25th (β = -0.07, p = 0.045), 50th (β = -0.07, p = 0.004) and 75th (β = -0.04, p = 0.035) percentiles.
Across the HRQoL, fatigue, and physical and functional well-being distributions, sedentary time was inversely associated with HRQoL, fatigue, and physical and functional well-being in lung cancer survivors. Small associations were observed between MVPA and fatigue, but no associations emerged with HRQoL or physical and functional well-being.
目前尚无研究从客观评估的角度来分析肺癌幸存者的体力活动、久坐时间和患者报告的结局。本研究旨在确定客观评估的中等到剧烈强度体力活动（MVPA）和久坐时间与肺癌幸存者的健康相关生活质量（HRQoL）和疲劳之间的关联。
艾伯塔省南部的肺癌幸存者（N=540）受邀完成了一项邮寄调查，该调查评估了 HRQoL（癌症治疗功能评估-肺部问卷（FACT-L））、身体和功能健康状况（试验结局指数（TOI））和疲劳（疲劳量表（FS））。使用 Actigraph GT3X+加速度计在臀部佩戴 7 天，收集体力活动和久坐时间的数据。使用分位数回归来检验 HRQoL 和疲劳与体力活动和久坐时间在 HRQoL 和疲劳第 25%、50%和 75%分位数的关联。
共有 127 名肺癌幸存者参与了研究，响应率为 24%（平均年龄为 71 岁；平均诊断后时间为 75 个月）。总 MVPA 分钟数与第 25%分位数时的疲劳症状减少呈正相关（β=0.16，p=0.046）。总久坐时间与第 75%分位数时的 HRQoL 呈负相关（β=-0.07，p=0.014），与第 50%分位数时的疲劳症状呈负相关（β=-0.04，p=0.009）。总久坐时间与身体和功能健康状况评分在第 25%（β=-0.07，p=0.045）、50%（β=-0.07，p=0.004）和 75%（β=-0.04，p=0.035）分位数时也呈负相关。
在整个 HRQoL、疲劳和身体与功能健康状况的分布中，久坐时间与肺癌幸存者的 HRQoL、疲劳和身体与功能健康状况呈负相关。MVPA 与疲劳之间存在较小的关联，但与 HRQoL 或身体与功能健康状况之间没有关联。
