Salat-Baroux J, Giacomini P, Antoine J M
Department of Obstetrics and Gynaecology, Tenon Hospital, University of Paris VI, France.
Hum Reprod. 1988 Feb;3(2):197-200. doi: 10.1093/oxfordjournals.humrep.a136676.
In order to evaluate the efficiency of Danazol treatment on pelvic endometriosis, a laparoscopic control with photographs was performed before treatment in 33 cases. Of these 20 were severe (group A), seven mild (group B) and six light (group C), according to the American Fertility Society classification, and 15 patients were infertile, 10 had pelvic pain and eight had dysmenorrhoea. Among the 28 patients who accepted a laparoscopic control after 6 months of treatment, the result was quite good in 50% of the cases in groups B and C, an improvement was seen in 30% of the patients in groups A and B, but a failure in 50% of the cases, especially in group A. Of the 14 cases with an ovarian cyst greater than 3 cm in diameter an operation was necessary either by laparoscopy (four cases) or by laparotomy (five cases). Seven pregnancies were established out of 15 cases of infertility, but a relapse was noticed in 30% of the cases. In conclusion, it appears that Danazol therapy is effective in mild or light endometriosis, but is not sufficient in cases of ovarian endometriosis with cysts greater than 3 cm in diameter.
为了评估达那唑治疗盆腔子宫内膜异位症的疗效，对33例患者在治疗前进行了腹腔镜检查并拍照。根据美国生育协会的分类，其中20例为重度（A组），7例为轻度（B组），6例为轻度（C组），15例患者不孕，10例有盆腔疼痛，8例有痛经。在28例接受6个月治疗后进行腹腔镜检查的患者中，B组和C组50%的病例效果相当好，A组和B组30%的患者有改善，但50%的病例治疗失败，尤其是A组。在14例直径大于3cm的卵巢囊肿患者中，有4例需要通过腹腔镜手术，5例需要通过剖腹手术。15例不孕患者中有7例怀孕，但30%的病例出现复发。总之，达那唑治疗轻度或轻度子宫内膜异位症似乎有效，但对直径大于3cm的卵巢子宫内膜异位症囊肿病例则不够充分。
