Set7介导的干细胞分化的当前观点。
Current perspectives in Set7 mediated stem cell differentiation.
作者信息
Karimnia Nazanin, Rafehi Haloom, Tuano Natasha K, Ziemann Mark, K N Harikrishnan, Okabe Jun, El-Osta Assam
机构信息
Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.
Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia.
出版信息
Noncoding RNA. 2016 Dec 4;2(4):14. doi: 10.3390/ncrna2040014.
Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.
Set7是一种关键的调节酶，参与组蛋白和非组蛋白赖氨酸残基的甲基化。这种赖氨酸甲基转移酶在干细胞分化过程中被诱导，并调节谱系特异性基因转录和细胞命运。在本文中，我们讨论了确定Set7控制下的调节靶点的最新实验证据，以及干细胞分化中调节的新出现证据。此外，我们还讨论了Set7调节的非编码RNA在细胞可塑性中的作用。
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