Ahmad Zaki, Moustafa Yara W, Stiller John W, Pavlovich Mary A, Raheja Uttam K, Gragnoli Claudia, Snitker Soren, Nazem Sarra, Dagdag Aline, Fang Beverly, Fuchs Dietmar, Lowry Christopher A, Postolache Teodor T
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA; and Saint Elizabeths' Hospital, Psychiatry Residency Training Program, Washington, DC, USA.
Pteridines. 2017;28(3-4):195-204. doi: 10.1515/pterid-2017-0010. Epub 2017 Nov 28.
() infects central nervous tissue and is kept in relative dormancy by a healthy immune system. Sleep disturbances have been found to precipitate mental illness, suicidal behavior and car accidents, which have been previously linked to as well. We speculated that if sleep disruption, particularly insomnia, would mediate, at least partly, the link between infection and related behavioral dysregulation, then we would be able to identify significant associations between sleep disruption and . The mechanisms for such an association may involve dopamine (DA) production by , or collateral effects of immune activation necessary to keep in check. Sleep questionnaires from 2031 Old Order Amish were analyzed in relationship to -IgG antibodies measured by enzyme-linked immunosorbent assay (ELISA). seropositivity and serointensity were not associated with any of the sleep latency variables or Epworth Sleepiness Scale (ESS). A secondary analysis identified, after adjustment for age group, a statistical trend toward shorter sleep duration in seropositive men (p = 0.07). In conclusion, it is unlikely that sleep disruption mediates links between and mental illness or behavioral dysregulation. Trending gender differences in associations between and shorter sleep need further investigation.
（）感染中枢神经组织，并在健康的免疫系统作用下处于相对休眠状态。睡眠障碍已被发现会引发精神疾病、自杀行为和车祸，这些此前也都与（此处前文未明确的某种因素）有关。我们推测，如果睡眠中断，尤其是失眠，会至少部分介导（此处前文未明确的某种因素）感染与相关行为失调之间的联系，那么我们就能确定睡眠中断与（此处前文未明确的某种因素）之间存在显著关联。这种关联的机制可能涉及（此处前文未明确的某种因素）产生多巴胺（DA），或者是控制（此处前文未明确的某种因素）所需的免疫激活的附带效应。分析了2031名旧秩序阿米什人的睡眠问卷，并将其与通过酶联免疫吸附测定（ELISA）测量的（此处前文未明确的某种因素）-IgG抗体进行关联分析。（此处前文未明确的某种因素）血清阳性和血清强度与任何睡眠潜伏期变量或爱泼华嗜睡量表（ESS）均无关联。在对年龄组进行调整后的二次分析中，发现血清阳性男性的睡眠时间有缩短的统计趋势（p = 0.07）。总之，睡眠中断不太可能介导（此处前文未明确的某种因素）与精神疾病或行为失调之间的联系。（此处前文未明确的某种因素）与较短睡眠时间之间关联的性别差异趋势需要进一步研究。
