Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Durango, Mexico.
Institute for Scientific Research "Dr. Roberto Rivera-Damm", Juárez University of Durango State, Durango, Mexico.
PLoS One. 2022 Jun 9;17(6):e0266214. doi: 10.1371/journal.pone.0266214. eCollection 2022.
We determined the association between Toxoplasma gondii (T. gondii) infection and insomnia. Through an age-and gender-matched case-control study, 577 people with insomnia (cases) and 577 people without insomnia (controls) were tested for anti-T. gondii IgG and IgM antibodies using commercially available enzyme-immunoassays. Anti-T. gondii IgG antibodies were found in 71 (12.3%) of 577 individuals with insomnia and in 46 (8.0%) of 577 controls (OR = 1.62; 95% CI: 1.09-2.39; P = 0.01). Men with insomnia had a higher (16/73: 21.9%) seroprevalence of T. gondii infection than men without insomnia (5/73: 6.8%) (OR: 3.81; 95% CI: 1.31-11.06; P = 0.009). The rate of high (>150 IU/ml) anti-T. gondii IgG antibody levels in cases was higher than the one in controls (OR = 2.21; 95% CI: 1.13-4.31; P = 0.01). Men with insomnia had a higher (8/73: 11.0%) rate of high anti-T. gondii IgG antibody levels than men without insomnia (0/73: 0.0%) (P = 0.006). The rate of high anti-T. gondii IgG antibody levels in cases >50 years old (11/180: 6.1%) was higher than that (3/180: 1.7%) in controls of the same age group (OR: 3.84; 95% CI: 1.05-14.00; P = 0.05). No difference in the rate of IgM seropositivity between cases and controls was found (OR = 1.33; 95% CI: 0.57-3.11; P = 0.50). Results of this seroepidemiology study suggest that infection with T. gondii is associated with insomnia. Men older than 50 years with T. gondii exposure might be prone to insomnia. Further research to confirm the association between seropositivity and serointensity to T. gondii and insomnia is needed.
我们确定了刚地弓形虫（Toxoplasma gondii，T. gondii）感染与失眠之间的关联。通过一项年龄和性别匹配的病例对照研究，对 577 名失眠症患者（病例）和 577 名非失眠症患者（对照）进行了抗刚地弓形虫 IgG 和 IgM 抗体检测，采用商业酶免疫分析试剂盒。在 577 例失眠症患者中，有 71 例（12.3%）发现抗刚地弓形虫 IgG 抗体，而在 577 例对照中，有 46 例（8.0%）发现抗刚地弓形虫 IgG 抗体（OR=1.62；95%CI：1.09-2.39；P=0.01）。与非失眠症男性（5/73：6.8%）相比，失眠症男性（16/73：21.9%）的刚地弓形虫感染血清阳性率更高（OR：3.81；95%CI：1.31-11.06；P=0.009）。病例组高（>150 IU/ml）抗刚地弓形虫 IgG 抗体水平的比例高于对照组（OR=2.21；95%CI：1.13-4.31；P=0.01）。失眠症男性（8/73：11.0%）的高抗刚地弓形虫 IgG 抗体水平率高于非失眠症男性（0/73：0.0%）（P=0.006）。>50 岁病例组（11/180：6.1%）的高抗刚地弓形虫 IgG 抗体水平率高于同年龄组对照组（3/180：1.7%）（OR：3.84；95%CI：1.05-14.00；P=0.05）。病例组和对照组之间 IgM 血清阳性率无差异（OR=1.33；95%CI：0.57-3.11；P=0.50）。这项血清流行病学研究的结果表明，刚地弓形虫感染与失眠有关。刚地弓形虫暴露的>50 岁男性可能容易患失眠症。需要进一步的研究来确认抗刚地弓形虫血清阳性率和血清强度与失眠症之间的关联。
