Horký K, Gutkowska J, Cantin M, Genet J, Garcia R
Kardiologiia. 1988 Jan;28(1):63-5.
The contribution of atrial natriuretic factor to the development of spontaneous arterial hypertension was investigated in rats (the SHR line). Prehypertensive atrial and plasma levels of a natriuretic factor were similar in SHR to those of the control WKY rats. In fully-developed hypertension, the factor content decreases in left-atrial wall and increases in the plasma. It is assumed that elevated arterial blood pressure affects myo-endocrine left-atrial cells, leading to hypersecretion of the natriuretic factor. This kind of secretory response might be an adaptive/compensatory mechanism of blood pressure control.
在大鼠（SHR品系）中研究了心房利钠因子对自发性动脉高血压发展的作用。高血压前期SHR大鼠心房和血浆中的利钠因子水平与对照WKY大鼠相似。在完全发展的高血压阶段，左心房壁中的因子含量降低，而血浆中的因子含量增加。据推测，动脉血压升高会影响心肌内分泌的左心房细胞，导致利钠因子分泌过多。这种分泌反应可能是一种血压控制的适应性/补偿机制。
