Macfarlane Tatiana V, Abbood Hadeel M, Pathan Ejaz, Gordon Katy, Hinz Juliane, Macfarlane Gary J
Epidemiology Group, University of Aberdeen School of Medicine, Medical Sciences and Nutrition, Aberdeen, UK.
Medicines Monitoring Unit, University of Dundee School of Medicine, Dundee, UK.
Eur J Rheumatol. 2018 Mar;5(1):45-52. doi: 10.5152/eurjrheum.2017.16103. Epub 2017 Oct 25.
The question of whether diet plays a role in the onset of ankylosing spondylitis (AS) or can affect the course of the disease is an important one for many patients and healthcare providers. The aims of this study were to investigate whether: 1) patients with AS report different diets to those without AS; 2) amongst patients with AS, diet is related to severity; 3) persons with particular diets are less likely to develop AS; 4) specific dietary interventions improve the AS symptoms. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Medline, Embase, Cochrane Library, and reference lists of relevant articles were searched. Two authors independently selected eligible studies, assessed the quality of included trials, and extracted the data. Sixteen studies (nine observational and seven interventions) were included in the review. Due to the heterogeneity of the study designs and analyses, the results could not be aggregated. Evidence on a possible relationship between AS and diet is extremely limited and inconclusive due to the majority of included studies being small, single studies with moderate-to-high risk of bias, and insufficient reporting of results.
饮食是否在强直性脊柱炎（AS）的发病中起作用或能否影响疾病进程的问题，对许多患者和医疗服务提供者来说至关重要。本研究的目的是调查：1）AS患者与非AS患者的饮食报告是否不同；2）在AS患者中，饮食与疾病严重程度是否相关；3）特定饮食的人群患AS的可能性是否较小；4）特定的饮食干预是否能改善AS症状。本综述按照系统评价和Meta分析的首选报告项目（PRISMA）指南进行。检索了Medline、Embase、Cochrane图书馆以及相关文章的参考文献列表。两位作者独立选择符合条件的研究，评估纳入试验的质量，并提取数据。本综述纳入了16项研究（9项观察性研究和7项干预性研究）。由于研究设计和分析的异质性，结果无法汇总。由于大多数纳入研究规模较小、为单一研究且存在中到高度偏倚风险，以及结果报告不足，关于AS与饮食之间可能关系的证据极其有限且尚无定论。
