手性钯催化的烯丙基烷基化反应在 Aspidosperma 和结构相关的单萜吲哚生物碱的合成中的应用。
Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids.
机构信息
The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd, MC 101-20, Pasadena, CA 91125, USA.
出版信息
Nat Prod Rep. 2018 Jun 20;35(6):559-574. doi: 10.1039/c7np00069c.
Abstract
Covering: up to the end of 2017 Enantioselective Pd-catalyzed allylic alkylations of prochiral enolates represent a powerful tool for the construction of all-carbon quaternary stereocenters. This review describes the emergence of such reactions as strategic linchpins that enable efficient, stereocontrolled syntheses of Aspidosperma and related monoterpene indole alkaloids.
摘要
涵盖
截至 2017 年底，手性钯催化前手性烯醇酯的对映选择性烯丙基烷基化反应是构建全碳季立体中心的有力工具。本综述描述了这些反应的出现，它们是有效、立体控制合成 Aspidosperma 和相关单萜吲哚生物碱的关键步骤。
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