Kulikova T G, Stepanova O V, Voronova A D, Valikhov M P, Sirotkin V N, Zhirov I V, Tereshchenko S N, Masenko V P, Samko A N, Sukhikh G T
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2018 Apr;164(6):794-797. doi: 10.1007/s10517-018-4082-1. Epub 2018 Apr 16.
Pathological remodeling of the myocardium in chronic heart failure includes the development of pathological cardiac hypertrophy, reactivation of the fetal genetic program, and disorders in cardiac energy metabolism. Coactivator-1α of receptor γ activated by peroxisome proliferator (PGC-1α), a transcription coactivator of nuclear receptors and metabolism master regulator, plays an important role in cardiac metabolism regulation. Studies on the animals models of chronic heart failure have demonstrated the development of pathological cardiac hypertrophy, metabolic disorders, and reactivation of the fetal genetic program; these processes are mutually related. An important role in regulation of these processes belongs to PGC-1α; its low expression indicates low activity and down-regulation of this coactivator. Pathological cardiac hypertrophy, decrease of PGC-1α activity, and reactivation of the fetal genetic program in chronic heart failure are demonstrated.
慢性心力衰竭时心肌的病理重塑包括病理性心肌肥大的发展、胎儿基因程序的重新激活以及心脏能量代谢紊乱。过氧化物酶体增殖物激活受体γ辅激活因子-1α（PGC-1α）是核受体的转录辅激活因子和代谢主调节因子，在心脏代谢调节中起重要作用。对慢性心力衰竭动物模型的研究表明，存在病理性心肌肥大、代谢紊乱和胎儿基因程序的重新激活；这些过程相互关联。PGC-1α在调节这些过程中起重要作用；其低表达表明该辅激活因子的活性降低和下调。慢性心力衰竭时存在病理性心肌肥大、PGC-1α活性降低和胎儿基因程序的重新激活。
