Institute for Complex Molecular Systems and Laboratory of Chemical Biology, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, P. O. Box 85500, 3584 CX, Utrecht, The Netherlands.
Adv Healthc Mater. 2018 Jun;7(11):e1701139. doi: 10.1002/adhm.201701139. Epub 2018 Apr 15.
Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.
可以通过磁共振成像（MRI）获得注射原位凝胶水凝胶的体内位置、形状、降解或侵蚀速率的信息。在此，用一种修饰的钆（III）-DOTA 络合物（UPy-Gd）对可注射的超分子尿嘧啶嘧啶酮基水凝胶（UPy-PEG）进行功能化，以用于对比增强 MRI。该造影剂被设计为与水凝胶网络超分子相互作用，以实现这种水凝胶的高质量成像。该方法的适用性通过在猪心脏中经靶向心内导管注射后成功可视化 Gd 标记的 UPy-PEG 水凝胶得到证明。
