从 中分离得到两个新的蒽醌衍生物和一个新的三芳基二苯甲酮类似物。
Two new anthraquinone derivatives and one new triarylbenzophenone analog from .
机构信息
Xiangya Hospital of Central South University , Changsha, China.
Xiangya School of Pharmaceutical Sciences, Central South University , Changsha, China.
出版信息
Nat Prod Res. 2020 Oct;34(19):2709-2714. doi: 10.1080/14786419.2018.1452008. Epub 2018 Apr 15.
Two new anthraquinone derivatives, selaginones A () and B (), and one new triarylbenzophenone analog, selagibenzophenone B (), were isolated from (Beauv.) Spring. Their structures were established by 1D-, 2D-NMR and HR-ESI-MS data. Compounds and represent the uncommon examples of aryl substituted anthraquinone derivatives. Especially, compound is a unique anthranone with exceptional structural feature, in which a -hydroxyphenyl moiety is attached to the C-10 position. Compound is the second naturally occurring triarylbenzophenone and showed moderate activity against SMCC-7721 and MHCC97-H cell lines with IC values of 39.8, 51.5 μM respectively.
从 （Beauv.） Spring 中分离得到两个新的蒽醌衍生物，即 selaginones A () 和 B ()，以及一个新的三芳基二苯甲酮类似物，selagibenzophenone B ()。通过 1D-NMR、2D-NMR 和 HR-ESI-MS 数据确定了它们的结构。化合物 和 代表了芳基取代蒽醌衍生物的罕见例子。特别是，化合物 是一种具有独特结构特征的独特蒽酮，其中一个 - 羟基苯基部分连接到 C-10 位置。化合物 是第二个天然存在的三芳基二苯甲酮，对 SMCC-7721 和 MHCC97-H 细胞系显示出中等的活性，IC 值分别为 39.8、51.5 μM。
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