从中分离得到一个新的三芳基茚满酮和一个新的异苯并呋喃酮衍生物。

A new triarylindanone and a new isobenzofuranone derivative from .

机构信息

Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, PR China.

Key Laboratory of Epigenetics and Oncology, Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.

出版信息

Nat Prod Res. 2022 Oct;36(20):5387-5392. doi: 10.1080/14786419.2021.1938042. Epub 2021 Jun 28.

DOI:10.1080/14786419.2021.1938042

PMID:34180326

Abstract

A new triarylindanone, namely selagindanone A (), and a new isobenzofuranone (), 3,4-bis(4-hydroxyphenyl)isobenzofuran-1(3)-one, were isolated from . Their structures were elucidated by comprehensive spectroscopic and mass spectrometric analyses, including 1 D-, 2 D-NMR and HR-ESI-MS. Compound possesses a unique structural feature of triaryl-substituted in the skeleton of 1-indanone. In addition, compound showed weak cytotoxicity against human hepatocellular carcinoma SMMC-7721 and HepG2 cell lines.

摘要

从中分离得到了一个新的三芳基茚满酮，即 selagindanone A ()，以及一个新的异苯并呋喃酮（），3,4-双(4-羟基苯基)异苯并呋喃-1(3)-酮。通过全面的光谱和质谱分析，包括 1D-、2D-NMR 和 HR-ESI-MS，确定了它们的结构。化合物具有 1-茚满酮骨架中三芳基取代的独特结构特征。此外，化合物对人肝癌 SMMC-7721 和 HepG2 细胞系表现出较弱的细胞毒性。