Audebert Christophe, Hot David, Caboche Ségolène
Gènes Diffusion, 3595, route de Tournai, 59501 Douai, France - Pegase-Biosciences, Institut Pasteur de Lille, 1, rue du professeur Calmette, 59019 Lille, France.
Univ Lille, CNRS, Inserm, CHU de Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Centre d'Infection et d'Immunité de Lille, 1, rue du professeur Calmette, F-59000 Lille, France - Pegase-Biosciences, Institut Pasteur de Lille, 1, rue du professeur Calmette, 59019 Lille, France.
Med Sci (Paris). 2018 Apr;34(4):319-325. doi: 10.1051/medsci/20183404012. Epub 2018 Apr 16.
High throughput sequencing has opened up new clinical opportunities moving towards a medicine of precision. Oncology, infectious diseases or human genomics, many applications have been developed in recent years. The introduction of a third generation of nanopore-based sequencing technology, addressing some of the weaknesses of the previous generation, heralds a new revolution. Portability, real time, long reads and marginal investment costs, these promising new technologies point to a new shift of paradigm. What are the perspectives opened up by nanopores for clinical applications?
高通量测序为迈向精准医学开辟了新的临床机遇。在肿瘤学、传染病或人类基因组学等领域，近年来已开发出许多应用。第三代基于纳米孔的测序技术的引入，弥补了上一代技术的一些不足，预示着一场新的革命。便携性、实时性、长读长以及较低的投资成本，这些颇具前景的新技术预示着一种新的范式转变。纳米孔技术在临床应用方面带来了哪些前景？
