Department of Clinical Radiology, Medical School, University of Ioannina, University Campus, Ioannina, Greece.
Department of Pathology, Medical School, University of Ioannina, University Campus, Ioannina, Greece.
J Magn Reson Imaging. 2018 Nov;48(5):1318-1325. doi: 10.1002/jmri.26050. Epub 2018 Apr 16.
The development of noninvasive imaging parameters having the capacity to identify the population of men with nonobstructive azoospermia (NOA) where a successful sperm retrieval outcome is of great clinical significance.
PURPOSE/HYPOTHESIS: To assess differences of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in NOA testes with impaired spermatogenesis and the possible association with the presence of spermatozoa after testicular sperm extraction (TESE).
Retrospective.
Twenty NOA men (35 testes) and 21 age-matched controls (36 testes).
FIELD STRENGTH/SEQUENCE: 1.5T, T WI-SE T WI-FSE FS SS-EP-DTI.
The MRI data were analyzed by two radiologists in consensus. The average ADC and FA of testicular parenchyma was measured. NOA testes were classified as NOA with higher Johnsen score (JS) ≥8 (group 1) and JS <8 (group 2).
Parametric and nonparametric statistical tests were used to compare ADC and FA between NOA groups and normal testes (group 3) and to evaluate a possible association with the presence of spermatozoa after TESE.
Differences in ADC were found between groups 1 and 2 (P = 0.043) and groups 2 and 3 (P = 0.004), but not between groups 1 and 3 (P = 0.418). Higher values of FA were found both in NOA testes with JS ≥8 (P < 0.001) and JS <8 (P < 0.001) compared to controls. ADC (P = 0.096) and FA (P = 0.516) did not demonstrate differences in NOA testes with or without spermatozoa at TESE.
Both ADC and FA are increased in NOA testes compared to a normal population. ADC was proven to be a more useful diagnostic adjunct tool in the identification of the population of NOA men with foci of advanced spermatogenesis. However, DTI parameters were not predictive of sperm retrieval after TESE.
4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:1318-1325.
开发具有识别非梗阻性无精子症（NOA）人群的无创成像参数的能力具有重要的临床意义，这些人群的精子提取有成功的可能。
目的/假设：评估生精功能受损的 NOA 睾丸的表观扩散系数（ADC）和各向异性分数（FA）的差异，以及与睾丸精子提取（TESE）后是否存在精子的相关性。
回顾性。
20 名 NOA 男性（35 个睾丸）和 21 名年龄匹配的对照组（36 个睾丸）。
磁场强度/序列：1.5T，T1 加权成像-SE 反转恢复 T2 加权成像-脂肪抑制序列-单次激发回波平面扩散加权成像。
由两位放射科医生对 MRI 数据进行了共识分析。测量睾丸实质的平均 ADC 和 FA。NOA 睾丸根据 Johnsen 评分（JS）分为更高的 JS≥8（组 1）和 JS＜8（组 2）。
采用参数和非参数统计检验比较 NOA 组与正常睾丸（组 3）之间的 ADC 和 FA，并评估其与 TESE 后精子存在的相关性。
组 1 与组 2（P=0.043）和组 2 与组 3（P=0.004）之间的 ADC 存在差异，但组 1 与组 3 之间的 ADC 无差异（P=0.418）。JS≥8（P＜0.001）和 JS＜8（P＜0.001）的 NOA 睾丸的 FA 值均高于对照组。TESE 后无精子的 NOA 睾丸的 ADC（P=0.096）和 FA（P=0.516）之间无差异。
与正常人群相比，NOA 睾丸的 ADC 和 FA 均升高。ADC 被证明是识别具有高级生精灶的 NOA 男性人群的更有用的诊断辅助工具。然而，DTI 参数不能预测 TESE 后的精子提取。
4 技术功效：3 级。磁共振成像杂志 2018；47：1318-1325.
