Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, AB T1K 3M4, Canada; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Neurobiol Learn Mem. 2019 Apr;160:21-31. doi: 10.1016/j.nlm.2018.04.004. Epub 2018 Apr 13.
Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of reactivation events between the hippocampus and cortical/subcortical structures, facilitated by the coupling of local field potential (LFP) oscillations (slow oscillations, sleep spindles and sharp wave/ripples) between these structures. We review the rapidly expanding literature on the qualitative and quantitative aspects of hippocampal oscillatory and neuronal coupling with cortical/subcortical structures in the context of memory reactivation. Reactivation in the hippocampus and cortical/subcortical structures is tightly coupled with sharp wave/ripples. Hippocampal-cortical/subcortical coupling is rich in dimensionality and this dimensionality is likely underestimated due to the limitations of the current methodology.
记忆巩固是一个渐进的过程，通过这个过程，情景记忆被整合到长期的“语义”表示中。它可能涉及在非快速眼动睡眠期间重新激活编码最近经验的神经活动。记忆巩固的一个关键前提是海马体和皮质/皮质下结构之间的重新激活事件的精确协调，这得益于这些结构之间局部场电位（LFP）振荡（慢波、睡眠纺锤波和锐波/涟漪）的耦合。我们回顾了关于记忆再激活背景下海马体振荡和神经元与皮质/皮质下结构耦合的定性和定量方面的快速发展的文献。海马体和皮质/皮质下结构中的再激活与锐波/涟漪紧密耦合。海马体-皮质/皮质下的耦合在维度上是丰富的，由于当前方法的限制，这种维度很可能被低估。
