Research Center for Health Sciences, Institute of Health, Department of Occupational Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Life Sci. 2018 Jun 1;202:182-187. doi: 10.1016/j.lfs.2018.04.020. Epub 2018 Apr 13.
This study was undertaken to ascertain whether light occupational exposure to pesticides by retailers might be associated with any liver, kidney, nervous system dysfunction or hematological abnormalities.
In this cross-sectional study, 70 male pesticide retailers (cases) and 64 male subjects, randomly selected from the constructions workers of city council contractors, as the referent group, were investigated. Urine and blood samples were taken from all subjects for urine analysis, hematological and biochemical parameters. Data analysis was conducted through SPSS v.19 using t-test and chi-square test.
The results of urine analysis showed that the frequency of abnormal urine tests was significantly higher in cases than in referent individuals. Similarly, the results of CBC showed that the mean values of monocyte, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin and platelet distribution width were significantly lower, and mean corpuscular hemoglobin concentration and red blood cell distribution width were significantly higher in retailers. No significant differences were found for other parameters.
These findings indicate that an association exists between exposure to pesticides by retailers and early subtle and sub-clinical changes in the urine tests and hematological parameters. Engineering measures are recommended to eliminate exposure to pesticides and to prevent its associated outcomes.
本研究旨在确定零售商轻度职业性接触农药是否与肝脏、肾脏、神经系统功能障碍或血液学异常有关。
在这项横断面研究中，对 70 名男性农药零售商（病例）和 64 名男性进行了调查，他们是市议会承包商建筑工人的随机选择，作为参照组。所有受试者均采集尿液和血液样本进行尿液分析、血液学和生化参数检测。数据分析采用 SPSS v.19 软件，采用 t 检验和卡方检验。
尿液分析结果显示，病例组异常尿液检测频率明显高于参照组个体。同样，CBC 结果显示，零售商单核细胞、血红蛋白、血细胞比容、平均红细胞体积、平均红细胞血红蛋白和血小板分布宽度的平均值明显较低，而平均红细胞血红蛋白浓度和红细胞分布宽度明显较高。其他参数无显著差异。
这些发现表明，零售商接触农药与尿液检测和血液学参数的早期细微和亚临床变化之间存在关联。建议采取工程措施消除接触农药的机会，预防其相关后果。
