Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran..
Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran.
Int J Biol Macromol. 2018 Aug;115:194-220. doi: 10.1016/j.ijbiomac.2018.04.034. Epub 2018 Apr 13.
Chitosan (CS), the second most plentiful natural polysaccharide next to cellulose, has valuable characteristics including biocompatibility, nontoxicity and biodegradability. CS is broken down in the human body to innocuous products (amino sugars). Hydrogels are polymeric materials with three dimensional networks retaining a huge quantity of water within their structures which are of great interest in biomedical/environmental applications. Usually, injectable hydrogels have functional groups which are sensitive to pH, temperature or irradiation stimuli. Injectable scaffolds can be formed in situ through stimuli-responsive effect and they can overcome the drawback of traditional scaffolds which require surgery in order to be placed on the desired tissue. The antibacterial/antifungal activities of chitosan-based hydrogels and their applications in controlled drug delivery/release systems, tissue engineering, preparation of injectable hydrogels and water treatment (removal of heavy/toxic metals and dyes) will be described. Moreover, the molecular dynamics (MD) simulation were performed on the delivery of the anticancer chlorambucil (CB) drug using three silica filled polymeric nanocomposites based on chitosan (CS), polylactic acid (PLA) and polyethylene glycol (PEG) and it was illustrated that among three drug delivery systems (DDSs), the CS nanocomposite was the most efficient DDS due to the lowest drug diffusion was measured for the CS system that could lead to the most sustained/controlled drug delivery.
壳聚糖（CS）是仅次于纤维素的第二大丰富的天然多糖，具有生物相容性、无毒和可生物降解等有价值的特性。CS 在人体内分解为无害产物（氨基糖）。水凝胶是具有三维网络的聚合物材料，在其结构中保留大量水分，在生物医学/环境应用中具有很大的兴趣。通常，可注射水凝胶具有对 pH 值、温度或辐照刺激敏感的官能团。可注射支架可以通过响应刺激原位形成，它们可以克服传统支架的缺点，传统支架需要手术才能放置在所需的组织上。将描述基于壳聚糖的水凝胶的抗菌/抗真菌活性及其在控制药物释放/释放系统、组织工程、制备可注射水凝胶和水处理（去除重金属/有毒金属和染料）中的应用。此外，还对使用三种基于壳聚糖（CS）、聚乳酸（PLA）和聚乙二醇（PEG）的填充有二氧化硅的聚合物纳米复合材料进行了抗癌药物氯苯丁酸（CB）输送的分子动力学（MD）模拟，结果表明，在三种药物输送系统（DDS）中，CS 纳米复合材料是最有效的 DDS，因为 CS 系统中药物扩散最低，这可能导致最持续/控制药物输送。
