Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Drug Discov Today. 2018 May;23(5):1159-1166. doi: 10.1016/j.drudis.2018.04.007. Epub 2018 Apr 13.
A variety of nanoplatforms have been developed and applied for cancer therapy, imaging, or the combination thereof. These nanoplatforms, combined with therapeutic and imaging functionalities, display great potential to enhance medical care. In particular, lipid-based nanoparticles (LNPs) are among the most-studied platforms that have resulted in many encouraging advances in theranostics. LNPs are biodegradable and biocompatible, and their formulation can be tailored for various applications. Here, we provide an overview of recent developments of four representative LNP platforms for theranostics: stealth liposomes, triggered-release liposomes, porphysomes, and lipid-coated calcium phosphate NPs (LCPs). We discuss their potential, limitations, and potential applications for cancer care and highlight perspectives and future directions for the nanotheranostics field.
已经开发并应用了多种纳米平台用于癌症治疗、成像或两者的结合。这些纳米平台结合治疗和成像功能，具有增强医疗保健的巨大潜力。特别是，基于脂质的纳米颗粒（LNPs）是研究最多的平台之一，它们在治疗学方面取得了许多令人鼓舞的进展。LNPs 是可生物降解和生物相容的，其配方可以针对各种应用进行定制。在这里，我们提供了四种用于治疗学的代表性 LNP 平台（隐形脂质体、触发释放脂质体、卟啉体和脂质包覆的磷酸钙 NPs（LCPs））的最新发展概述。我们讨论了它们在癌症治疗中的潜力、局限性和潜在应用，并强调了纳米治疗学领域的观点和未来方向。
