Bukhari Syeda Zunaira, Zeth Kornelius, Iftikhar Maryam, Rehman Mubashar, Usman Munir Muhammad, Khan Waheed S, Ihsan Ayesha
National Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, Pakistan.
Department of Science and Environment, Roskilde University Center, DK-4000 Roskilde, Denmark.
Curr Res Pharmacol Drug Discov. 2021 Oct 28;2:100067. doi: 10.1016/j.crphar.2021.100067. eCollection 2021.
Nanotheranostics is an emerging frontier of personalized medicine research particularly for cancer, which is the second leading cause of death. Supramolecular aspects in theranostics are quite allured to achieve more regulation and controlled features. Supramolecular nanotheranostics architecture is focused on engineering of modular supramolecular assemblies benefitting from their mutable and stimuli-responsive properties which confer an ultimate potential for the fabrication of unified innovative nanomedicines with controlled features. Amalgamation of supramolecular approaches to nano-based features further equip the potential of designing novel approaches to overcome limitations seen by the conventional theranostic strategies, for curing even the lethal diseases and endowing personalized therapeutics with optimistic prognosis, endorsing their clinical translation. Among many potential nanocarriers for theranostics, lipid nanoparticles (LNPs) have shown various promising advances in theranostics and their formulation can be tailored for several applications. Despite the great advancement in cancer nanotheranostics, there are still many challenges that need to be highlighted to fill the literature gap. For this purpose, herein, we have presented a systematic overview on the subject and proposed LNPs as the potential material to manage cancer via non-invasive approaches by highlighting the use of supramolecular approaches to make them robust for cancer theranostics. We have concluded the review by entailing the future perspectives of lipid nanotheranostics towards clinical translation.
纳米诊疗学是个性化医学研究中一个新兴的前沿领域，尤其针对癌症，癌症是第二大致死原因。诊疗学中的超分子方面极具吸引力，能够实现更多的调控和可控特性。超分子纳米诊疗学架构专注于模块化超分子组装体的工程设计，受益于其可变和刺激响应特性，这为制造具有可控特性的统一创新纳米药物提供了巨大潜力。将超分子方法与基于纳米的特性相结合，进一步提升了设计新方法的潜力，以克服传统诊疗策略所面临的局限性，治愈甚至是致命疾病，并为个性化治疗带来乐观的预后，推动其临床转化。在众多用于诊疗学的潜在纳米载体中，脂质纳米颗粒（LNPs）在诊疗学方面展现出了各种有前景的进展，其制剂可针对多种应用进行定制。尽管癌症纳米诊疗学取得了巨大进展，但仍有许多挑战需要凸显，以填补文献空白。为此，在本文中，我们对该主题进行了系统综述，并提出脂质纳米颗粒作为通过非侵入性方法管理癌症的潜在材料，强调利用超分子方法使其在癌症诊疗学中更具优势。我们通过阐述脂质纳米诊疗学临床转化的未来前景来结束本综述。
