Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Asian J Psychiatr. 2018 Apr;34:67-73. doi: 10.1016/j.ajp.2017.11.026. Epub 2017 Nov 28.
Schizophrenia is a disabling psychiatric disorder. The role of Borna Disease Virus (BDV) in the etiology of schizophrenia has been suggested by several studies. However, the existence of such association remained controversial. The present meta-analysis was conducted to evaluate this association.
This systematic review and meta-analysis was conducted using preferred reporting items for systematic reviews and meta-analysis (PRISMA). Online databases including Scopus, PubMed, Science direct, Embase, PsycINFO, Web of Science and Google scholar search engine were searched until January 15, 2017. The heterogeneity of the studies was evaluated using Cochran's Q test and I statistic. Finally, random effects model was used for combining the results using Stata software version 11.1.
Overall, 30 studies containing 2533 cases and 4004 controls were included in the meta-analysis. The combined odds ratio (OR) for the relationship between BDV and schizophrenia was estimated to be 2.72 (95%CI: 1.75-4.20). This association based on RT-PCR, WB, IFA, EIA, RLA, ECLIA methods was estimated to be 3.83 (95%CI: 1.59-9.20), 4.99 (95%CI: 1.80-13.85), 1.27 (95%CI: 0.23-7.12), 2.26 (95%CI: 0.48-10.64), 1.67 (95%CI: 0.50-5.56) and 2.88 (95%CI: 1.38-6.01), respectively. Subgroup analysis according to WBC, serum and plasma samples was estimated to be 3.31 (95%CI: 1.19-9.25), 2.21 (95% CI: 1.17-4.17), 2.21 (95%CI: 1.03-4.73) and 7.89 (95%CI: 1.75-35.53), respectively.
The results indicated the role of BDV in the etiology of schizophrenia.
精神分裂症是一种使人丧失能力的精神疾病。有几项研究表明，博尔纳病病毒（BDV）在精神分裂症的病因学中起作用。然而，这种关联的存在仍然存在争议。本荟萃分析旨在评估这种关联。
本系统评价和荟萃分析使用系统评价和荟萃分析的首选报告项目（PRISMA）进行。在线数据库包括 Scopus、PubMed、Science direct、Embase、PsycINFO、Web of Science 和 Google scholar 搜索引擎，检索至 2017 年 1 月 15 日。使用 Cochran's Q 检验和 I 统计评估研究的异质性。最后，使用 Stata 软件版本 11.1 采用随机效应模型对结果进行合并。
总体而言，30 项研究共纳入 2533 例病例和 4004 例对照，纳入荟萃分析。BDV 与精神分裂症之间关系的合并优势比（OR）估计为 2.72（95%CI：1.75-4.20）。基于 RT-PCR、WB、IFA、EIA、RLA、ECLIA 方法的这种关联估计为 3.83（95%CI：1.59-9.20）、4.99（95%CI：1.80-13.85）、1.27（95%CI：0.23-7.12）、2.26（95%CI：0.48-10.64）、1.67（95%CI：0.50-5.56）和 2.88（95%CI：1.38-6.01）。根据白细胞计数（WBC）、血清和血浆样本的亚组分析估计为 3.31（95%CI：1.19-9.25）、2.21（95%CI：1.17-4.17）、2.21（95%CI：1.03-4.73）和 7.89（95%CI：1.75-35.53）。
结果表明 BDV 在精神分裂症的病因学中起作用。
