Suppr超能文献

[2至12岁儿童扁桃体切除术后镇痛药的需求]

[Need of analgetics in children aged 2-12 years after tonsil surgery].

作者信息

Gude Philipp, Rieckert Claudia, Bissantz Nicolai, Weber Thomas Peter, Vogelsang Heike, Dazert Stefan, Thomas Jan Peter

机构信息

Katholisches Klinikum Bochum Klinik für Anästhesiologie und Intensivmedizin.

Ruhr-Universität Bochum Fakultät für Mathematik, Lehrstuhl für Stochastik.

出版信息

Laryngorhinootologie. 2018 Jul;97(7):465-473. doi: 10.1055/a-0596-7675. Epub 2018 Apr 16.

Abstract

OBJECTIVE

Tonsil surgery is one of the most painful operations in childhood. The Children's and Infants' Postoperative Pain Scale (CHIPPS), the Faces Pain Scale-Revised (FPS-R) and the little-known German version of the parents' postoperative pain measure (PPPM-D) are age-appropriate measures. Children undergoing intracapsular tonsillectomy (TO) or extracapsular tonsillectomy (TE) received the non-opioids ibuprofen (IBU) and paracetamol (PCM) on a "as needed"-basis requested by parents. A pain service checked pain scales and applied piritramide as rescue medication (RM) if required. Objective was evalution of sufficient analgesia. Endpoints were number of patients (PAT) needing the RM, doses of requested non-opioids, consistency of indications in different pain scales and correlation between pain and efficacy of the premedication or duration of the intervention.

MATERIAL/METHODS: 3 measures were carried out daily: CHIPPS for PAT ≤ 4 years old, FPS-R from the age of 5. Parents completed the PPPM-D. Exceeding a cut-off score of 4 in CHIPPS or FPS-R or 6 in PPPM-D was rated as indication for RM.

RESULTS

We included 68 PAT in an interim analysis. Mean daily doses of non-opioids within the first 3 postoperative days were as follows: PAT undergoing TE got 14,1-16,3 mg/Kg IBU and 4,2-12,4 mg/Kg PCM. PAT undergoing TO got 10,8-14,7 mg/Kg IBU and 5,2-8,8 mg/Kg PCM. On 212 visits PAT required RM, but 121 times it was detected in the PPPM-D only. After exclusion of potentially false-positive results remained 67 % PAT after TE and 48 % PAT after TO with at least 1 indication for RM. The study was terminated due to the high need for RM.

CONCLUSIONS

The need of non-opioids was underrated. Combining the PPPM-D with established measures may improve the postoperative pain therapy.

摘要

目的

扁桃体手术是儿童期最痛苦的手术之一。儿童和婴幼儿术后疼痛量表(CHIPPS)、面部疼痛量表修订版(FPS-R)以及鲜为人知的德国版家长术后疼痛测量表(PPPM-D)都是适合相应年龄段的测量工具。接受囊内扁桃体切除术(TO)或囊外扁桃体切除术(TE)的儿童根据家长要求按需服用非阿片类药物布洛芬(IBU)和对乙酰氨基酚(PCM)。疼痛服务团队检查疼痛量表,并在需要时应用匹米诺定作为急救药物(RM)。目的是评估镇痛效果是否充分。终点指标包括需要急救药物的患者数量(PAT)、所要求的非阿片类药物剂量、不同疼痛量表中指征的一致性以及术前用药疼痛与疗效或干预持续时间之间的相关性。

材料/方法:每天进行3项测量:4岁及以下患者使用CHIPPS,5岁及以上患者使用FPS-R。家长完成PPPM-D。CHIPPS或FPS-R评分超过4分或PPPM-D评分超过6分被评定为需要急救药物的指征。

结果

在一项中期分析中纳入了68例患者。术后前3天非阿片类药物的平均每日剂量如下:接受TE的患者服用14.1 - 16.3毫克/千克IBU和4.2 - 12.4毫克/千克PCM。接受TO的患者服用10.8 - 14.7毫克/千克IBU和5.2 - 8.8毫克/千克PCM。在212次访视中患者需要急救药物,但其中121次仅在PPPM-D中检测到。排除潜在的假阳性结果后,TE术后仍有67%的患者和TO术后有48%的患者至少有1次需要急救药物的指征。由于对急救药物的高需求,该研究终止。

结论

非阿片类药物的需求被低估了。将PPPM-D与既定测量方法相结合可能会改善术后疼痛治疗。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验