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大剂量布洛芬作为一种按需 24 小时不间断的单药疗法,无法控制行扁桃体切除术的儿童的疼痛:一项前瞻性观察性队列研究。

High dose ibuprofen as a monotherapy on an around-the-clock basis fails to control pain in children undergoing tonsil surgery: a prospective observational cohort study.

机构信息

Department of Anaesthesiology, St. Josef and St. Elisabeth Hospital, Ruhr-University Bochum, Gudrunstraße 56, 44791, Bochum, Germany.

Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth Hospital, Ruhr-University Bochum, Bochum, Germany.

出版信息

Eur Arch Otorhinolaryngol. 2020 Jul;277(7):2115-2124. doi: 10.1007/s00405-020-05929-5. Epub 2020 Apr 3.

Abstract

PURPOSE

The optimal pain management concept in children after tonsil surgery is controversial. Ibuprofen on an "around-the-clock" basis has been suggested to control postoperative pain sufficiently. Therefore, we established a standard scheme with weight-adapted recommended maximum ibuprofen dose. A reliable assessment of pain intensity can be performed with the Children's and Infants' Postoperative Pain Scale (CHIPPS) in children < 5 years, or with the Faces Pain Scale-Revised (FPS-R) in children aged ≥ 5 years. The Parents' Postoperative Pain Measure (PPPM-D) may be a useful tool for both age groups. We hypothesized that not more than 30% of the children would need an opioid rescue medication during their in-hospital stay and analyzed the consistency of the PPPM-D with other pain scales.

METHODS

We included 158 in-patients aged 2-12 years. Ibuprofen was orally administered every 8 h. Three times daily, pain scores were assessed by CHIPPS or FPS-R, respectively. The PPPM-D was used in all children. Exceeding the cut-off value in one of the tools was regarded as relevant pain.

RESULTS

A rescue medication was needed in 82.1% of children after tonsillectomy and 51.3% of children after tonsillotomy (P < 0.001). The cut-off value for relevant pain was mostly exceeded in the PPPM-D, but its overall concordance to the reference scales was low.

CONCLUSION

High-dose ibuprofen "around-the-clock" is insufficient to control pain in children after tonsil surgery. Research is needed to find an optimal schema for management and assessment of postoperative pain.

摘要

目的

儿童扁桃体手术后的最佳疼痛管理概念存在争议。建议采用“全天候”布洛芬方案来充分控制术后疼痛。因此,我们建立了一个标准方案,根据体重调整推荐的最大布洛芬剂量。<5 岁的儿童可以使用儿童和婴儿术后疼痛量表(CHIPPS),≥5 岁的儿童可以使用面部疼痛量表修订版(FPS-R)来可靠地评估疼痛强度。父母术后疼痛量表(PPPM-D)可能是两个年龄段都有用的工具。我们假设在住院期间,接受手术的儿童中不超过 30%需要阿片类药物的急救药物,并分析了 PPPM-D 与其他疼痛量表的一致性。

方法

我们纳入了 158 名 2-12 岁的住院患者。每 8 小时口服一次布洛芬。每天三次,分别使用 CHIPPS 或 FPS-R 评估疼痛评分。所有儿童均使用 PPPM-D。如果其中一种工具的临界值超过,则认为有相关疼痛。

结果

扁桃体切除术和扁桃体切除术的儿童中,分别有 82.1%和 51.3%的儿童需要急救药物(P<0.001)。在 PPPM-D 中,大多超过了相关疼痛的临界值,但与参考量表的整体一致性较低。

结论

“全天候”大剂量布洛芬不足以控制扁桃体手术后儿童的疼痛。需要研究找到一种管理和评估术后疼痛的最佳方案。

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