结核性脑膜炎患者的人类免疫缺陷病毒：系统评价和荟萃分析。
Human immunodeficiency virus in patients with tuberculous meningitis: systematic review and meta-analysis.
机构信息
Student Research Committee, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Trop Med Int Health. 2018 Jun;23(6):589-595. doi: 10.1111/tmi.13059. Epub 2018 May 21.
INTRODUCTION
Human immunodeficiency virus (HIV)-infected individuals are at increased risk for all forms of extrapulmonary tuberculosis (TB), including tuberculous meningitis (TBM). This study aimed to investigate the frequency of HIV in patients with TBM.
METHODS
PubMed, Embase, Web of Science and Cochrane Library were searched for articles including relevant data. Stata version 14.0 (StataCorp, College Station, Texas, USA) was used to analyse the data.
RESULTS
Twenty studies were identified. The pooled frequency of HIV among adult patients with TBM was 38.0% (95% CI: 21.0-57.0; I = 97%). In children (under the age of 15 years), 6.0% (95% CI: 1.0-13.0; I = 0.0%) had HIV infection. In patients with bacterial meningitis other than TBM, 36.0% (95% CI: 19.0-53.0; I = 100%) were HIV-infected.
CONCLUSIONS
A relatively high frequency of HIV in patients with TBM was indicated by our study. Establishment of diagnostic criteria and effective treatment strategies for TBM/HIV co-infection are recommended for better management of patients with TBM+HIV.
简介
感染人类免疫缺陷病毒 (HIV) 的个体患各种肺外结核病（TB）的风险增加，包括结核性脑膜炎（TBM）。本研究旨在调查 TBM 患者中 HIV 的频率。
方法
检索 PubMed、Embase、Web of Science 和 Cochrane Library 中的包含相关数据的文章。使用 Stata 版本 14.0（StataCorp，德克萨斯州学院站，美国）分析数据。
结果
确定了 20 项研究。成人 TBM 患者中 HIV 的合并频率为 38.0%（95%CI：21.0-57.0；I = 97%）。在儿童（15 岁以下）中，有 6.0%（95%CI：1.0-13.0；I = 0.0%）感染了 HIV。在非 TBM 的细菌性脑膜炎患者中，有 36.0%（95%CI：19.0-53.0；I = 100%）感染了 HIV。
结论
我们的研究表明，TBM 患者中 HIV 的频率相对较高。建议为 TBM/HIV 合并感染建立诊断标准和有效的治疗策略，以更好地管理 TBM+HIV 患者。
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