HIV 与结核性脑膜炎合并感染：一项系统评价与荟萃分析

HIV-Tuberculous Meningitis Co-Infection: A Systematic Review and Meta-Analysis.

作者信息

Purmohamad Ali, Azimi Taher, Nasiri Mohammad J, Goudarzi Mehdi, Zangiabadian Moein, Sedighian Hamid, Fooladi Abbas A I

机构信息

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Curr Pharm Biotechnol. 2021;22(7):960-968. doi: 10.2174/1389201021666200730143906.

DOI:10.2174/1389201021666200730143906

PMID:32744963

Abstract

Human Immunodeficiency Virus (HIV)-infected persons are at a higher risk of developing Tuberculous Meningitis (TBM). We aimed to estimate the prevalence of TBM-HIV co-infection. We systematically searched Pubmed/Medline, Embase and Cochrane library databases from January 1, 2000, to January 31, 2017, to find relevant studies. We employed the random-effects meta-analysis model to estimate the pooled prevalence of TBM-HIV co-infection. Twenty-six eligible studies showed the prevalence of HIV in TBM patients. In the pooled analyses, the prevalence of HIV was 30% (95% CI: 12-47) in patients with confirmed TBM, and 12.1% (95% CI: 7.3-19.2) in patients with suspected TBM. This study shows a high prevalence of TBM-HIV co-infection. Establishing proper diagnostic criteria and preventive measures for TBM infections could assist in the prevention and management of TBM infection, particularly TBM-HIV co-infection.

摘要

感染人类免疫缺陷病毒（HIV）的人患结核性脑膜炎（TBM）的风险更高。我们旨在估计TBM-HIV合并感染的患病率。我们系统检索了2000年1月1日至2017年1月31日期间的Pubmed/Medline、Embase和Cochrane图书馆数据库，以查找相关研究。我们采用随机效应荟萃分析模型来估计TBM-HIV合并感染的合并患病率。26项符合条件的研究显示了TBM患者中HIV的患病率。在汇总分析中，确诊TBM的患者中HIV患病率为30%（95%CI：12-47），疑似TBM的患者中HIV患病率为12.1%（95%CI：7.3-19.2）。本研究显示TBM-HIV合并感染的患病率很高。建立适当的TBM感染诊断标准和预防措施有助于TBM感染的预防和管理，特别是TBM-HIV合并感染。