Brun Jean-Frédéric, Varlet-Marie Emmanuelle, Richou Marlène, Mercier Jacques, Raynaud de Mauverger Eric
U1046 INSERM, UMR 9214 CNRS « Physiopathologie and Médecine Expérimentale du Coeur et des Muscles-PHYMEDEXP », Unité d'ExplorationsMétaboliques (CERAMM), Université de Montpellier, Département de Physiologie Clinique, Hôpital Lapeyronie CHRU Montpellier, France.
Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247, Université de Montpellier, Ecole Nationale Supérieure de Chimie de Montpellier, France.
Clin Hemorheol Microcirc. 2018;69(1-2):239-265. doi: 10.3233/CH-189124.
Rheological properties of plasma and blood cells are markedly influenced by the surrounding milieu: physicochemical factors, metabolism and hormones. Acid/base status, osmolality, lipid status, plasma protein pattern, oxidative stress induced by increased free radicals production, endothelium-derived factors such as nitric oxide (NO), achidonic acid derivatives modulate both red blood cell (RBC) and white cell mechanics. Therefore, regulatory axes involving liver, endothelium, kidney, pancreas, adrenal gland, endocrine heart, adipose tissue, pituitary gland, and surely other tissues play important roles in the regulation of blood fluidity. A comprehensive picture of all this complex network of regulatory loops is still unavailable but current progress of knowledge suggest that some attempts can currently be made.
物理化学因素、新陈代谢和激素。酸碱状态、渗透压、脂质状态、血浆蛋白模式、自由基产生增加所诱导的氧化应激、内皮衍生因子如一氧化氮（NO）、花生四烯酸衍生物，均可调节红细胞（RBC）和白细胞的力学特性。因此，涉及肝脏、内皮、肾脏、胰腺、肾上腺、内分泌心脏、脂肪组织、垂体，当然还有其他组织的调节轴，在血液流动性调节中发挥着重要作用。目前仍无法全面了解所有这些复杂的调节回路网络，但当前的知识进展表明，目前可以进行一些尝试。
