Valeanu Liana, Ginghina Carmen, Bubenek-Turconi Serban
Cardiac Anaesthesiology and Intensive Care Department I, Emergency Institute for Cardiovascular Diseases, Prof. dr. C. C. Iliescu, 258 Fundeni Road, 022328, Bucharest, Romania.
Anaesthesiology and Intensive Care Department, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474, Bucharest, Romania.
Rom J Anaesth Intensive Care. 2022 Dec 29;28(2):41-46. doi: 10.2478/rjaic-2021-0007. eCollection 2021 Dec.
Blood rheology is an important determinant of blood flow but is probably one of the most neglected areas in clinical literature and practice. Blood viscosity changes according to shear rates and depends on cellular and plasma factors. RBCs' aggregability and deformability are the main determinants of local flow characteristics in areas with lower and higher shear rates, but plasma viscosity is the main regulatory factor of flow resistance in the microcirculation. In individuals with altered blood rheology, the mechanical stress to vascular walls induces endothelial injury and vascular remodelling, and promotes atherosclerosis. Increased values of whole blood viscosity and plasma viscosity are correlated with cardiovascular risk factors and adverse cardiovascular events. The long-term effects of physical exercise can produce a hemorheological fitness that protects against cardiovascular diseases.
血液流变学是血流的一个重要决定因素，但可能是临床文献和实践中最被忽视的领域之一。血液粘度根据剪切速率而变化，并取决于细胞和血浆因素。红细胞的聚集性和可变形性是剪切速率较低和较高区域局部血流特征的主要决定因素，但血浆粘度是微循环中血流阻力的主要调节因素。在血液流变学改变的个体中，血管壁的机械应力会导致内皮损伤和血管重塑，并促进动脉粥样硬化。全血粘度和血浆粘度的升高与心血管危险因素和不良心血管事件相关。体育锻炼的长期效果可以产生一种血液流变学适应性，从而预防心血管疾病。
