Medical Pathology Department, School of Medicine, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Virology Laboratory, Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Mycoses. 2018 Aug;61(8):587-593. doi: 10.1111/myc.12782. Epub 2018 Jun 20.
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis among immunocompetent patients in Latin America. This study aimed to describe the expansion over time and the geographical distribution of confirmed Neuroparacoccidioidomycosis (NPCM) and PCM cases, and relate it to environmental characteristics such as climate, soil types and coffee crops. This was a retrospective study of autopsy and biopsy reports between 1951 and 2014 from the Medical Pathology Section of the Hospital de Clinicas, Universidade Federal do Paraná (UFPR), Curitiba, Southern Brazil. PCM was predominant in male agricultural workers. PCM cases predominated in areas with subtropical climate with hot summers in North West Parana state. NPCM cases were distributed statewide more frequent in rural than metropolitan area. There was no association with climate, soil type, or coffee crop culture. Most of the PCM cases were in the metropolitan area of the capital, chiefly due to migration fluxes. Even though the history is predominantly agricultural, PCM cases were distributed mainly in the metropolitan area of the state capital, there was no association with climate and soil. NPCM cases were numerically more frequent in rural than metropolitan area.
副球孢子菌病（PCM）是中南美洲免疫功能正常患者中最常见的系统性真菌病。本研究旨在描述时间上的扩展和确诊的神经副球孢子菌病（NPCM）和 PCM 病例的地理分布，并将其与气候、土壤类型和咖啡种植等环境特征联系起来。这是对巴西南部库里蒂巴联邦大学临床医院医学病理学科 1951 年至 2014 年间尸检和活检报告的回顾性研究。PCM 主要发生在男性农业工人中。PCM 病例主要发生在西北部巴拉那州具有亚热带气候和炎热夏季的地区。NPCM 病例在全州范围内农村地区比大都市地区更为常见。与气候、土壤类型或咖啡种植均无关联。大多数 PCM 病例发生在首都的大都市区，主要是由于移民潮。尽管历史上主要是农业，但 PCM 病例主要分布在州府的大都市区，与气候和土壤没有关联。NPCM 病例在农村地区比大都市地区更为常见。
