Naghshvarian Mojtaba, Zarrindast Mohammad-Reza, Sajjadi Seyedeh Fatemeh
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2017 Dec 1;20(12):740-745.
Research evidence shows that exercise is associated with positive physical and mental health. Moreover, exercise and wheel running in rats activate overlapping neural systems and reward system. The most commonly used models for the study of rewarding and aversive effects of exercise involve using treadmill and wheel running paradigms in mice or rats. The purpose of our experiment was to study the influence of continuous voluntary exercise on exercise-seeking behavior.
In this experimental study, we used 24 adult male Sprague-Dawley rats weighing 275-300 g on average. Rats were divided into 3 experimental groups for 4 weeks of voluntary wheel running. Each rat ran in the cage equipped with a wheel during 24 hours. A within-subject repeated measure design was employed to evaluate the trend of running and running rates.
We found that time and higher levels of exercise will increase exercise tendency. Our results also show that the interaction of exercise within 4 weeks and different levels of exercise can significantly promote rats' exercise-seeking behavior (F = 5.440; df = 2.08; P < 0.001).
Our data suggest that voluntary wheel running can increase the likelihood of extreme and obsessive exercising which is a form of non-drug addiction.
研究证据表明，运动与积极的身心健康相关。此外，大鼠的运动和轮转跑步会激活重叠的神经系统和奖赏系统。研究运动奖赏和厌恶效应最常用的模型包括在小鼠或大鼠中使用跑步机和轮转跑步范式。我们实验的目的是研究持续自愿运动对运动寻求行为的影响。
在这项实验研究中，我们使用了24只成年雄性斯普拉格-道利大鼠，平均体重275 - 300克。将大鼠分为3个实验组，进行4周的自愿轮转跑步。每只大鼠在配备有轮子的笼子里24小时不间断地跑步。采用受试者内重复测量设计来评估跑步时间和跑步速度的变化趋势。
我们发现运动时间和更高的运动水平会增加运动倾向。我们的结果还表明，4周内的运动与不同运动水平之间的相互作用能够显著促进大鼠的运动寻求行为（F = 5.440；自由度 = 2.08；P < 0.001）。
我们的数据表明，自愿轮转跑步会增加极端和强迫性运动的可能性，这是一种非药物成瘾的形式。
