Leimbacher Aurelia C, Villiger Philipp, Desboeufs Nina, Aboouf Mostafa A, Nanni Monica, Armbruster Julia, Ademi Hyrije, Flüchter Pascal, Ruetten Maja, Gantenbein Felix, Haider Thomas J, Gassmann Max, Thiersch Markus
Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland.
iScience. 2023 Jul 10;26(8):107298. doi: 10.1016/j.isci.2023.107298. eCollection 2023 Aug 18.
Physical exercise can lower lung cancer incidence. However, its effect on lung cancer progression is less understood. Studies on exercising mice have shown decreased ectopic lung cancer growth through the secretion of interleukin-6 from muscles and the recruitment of natural killer (NK) cells to tumors. We asked if exercise suppresses lung cancer in an orthotopic model also. Single-housed C57Bl/6 male mice in cages with running wheels were tail vein-injected with LLC1.1 lung cancer cells, and lung tumor nodules were analyzed. Exercise did not affect lung cancer. Therefore, we also tested the effect of exercise on a subcutaneous LLC1 tumor and a tail vein-injected B16F10 melanoma model. Except for one case of excessive exercise, tumor progression was not influenced. Moderately exercising mice did not increase IL-6 or recruit NK cells to the tumor. Our data suggest that the exercise dose may dictate how efficiently the immune system is stimulated and controls tumor progression.
体育锻炼可以降低肺癌发病率。然而，其对肺癌进展的影响尚不太清楚。对运动小鼠的研究表明，通过肌肉分泌白细胞介素-6以及将自然杀伤（NK）细胞募集到肿瘤部位，可减少异位肺癌的生长。我们想知道运动在原位模型中是否也能抑制肺癌。将单笼饲养在带有跑步轮笼子里的C57Bl/6雄性小鼠经尾静脉注射LLC1.1肺癌细胞，并对肺肿瘤结节进行分析。运动对肺癌没有影响。因此，我们还测试了运动对皮下LLC1肿瘤和尾静脉注射的B16F10黑色素瘤模型的影响。除了一例过度运动的情况外，肿瘤进展未受影响。适度运动的小鼠不会增加白细胞介素-6的分泌，也不会将NK细胞募集到肿瘤部位。我们的数据表明，运动剂量可能决定免疫系统刺激和控制肿瘤进展的效率。
