Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
Human Anatomy & Histology, Department of Biomedical & Biotechnology Sciences, University of Catania, Catania, Italy.
Future Oncol. 2018 Mar;14(6s):59-62. doi: 10.2217/fon-2017-0389.
An environmental contamination due to an asbestiform mineral fiber, fluoro-edenite (FE), caused a significantly increased mortality rate for malignant mesothelioma in Biancavilla, Italy. Exposure to fluoro-edenite has been associated with inflammatory processes as an early response to inhaled fibers. The aim was to explore prevalence of anti-nuclear autoantibodies (ANA) in a group of construction workers residing and working in the contaminated area. Prevalences for samples positive to ANA were 60% (n = 9) and 13% (n = 2), for exposed and nonexposed, respectively (p-value <0.05), the odds ratio was 9.75 (95% CI: 1.59-59.69). The significance of elevated ANAs in subjects exposed to fibers is unknown; additional studies may provide a better opportunity to establish a correlation between autoimmunity and environmental exposure.
一种含石棉状矿物纤维的环境污染物质——氟透闪石（FE），导致意大利比安卡维拉恶性间皮瘤的死亡率显著上升。接触氟透闪石与吸入纤维后作为早期反应的炎症过程有关。本研究旨在探讨居住和工作在污染地区的一组建筑工人的抗核自身抗体（ANA）的流行情况。暴露组和非暴露组的 ANA 阳性样本的流行率分别为 60%（n=9）和 13%（n=2）（p 值<0.05），比值比为 9.75（95%CI：1.59-59.69）。暴露于纤维的个体中升高的 ANA 的意义尚不清楚；进一步的研究可能提供更好的机会来确定自身免疫与环境暴露之间的相关性。
