Department 'G.F. Ingrassia', Section of Anatomic Pathology, University of Catania, Catania, Italy.
Department of Biomedical & Biotechnological Sciences, Section of Anatomy & Histology, University of Catania, Catania, Italy.
Future Oncol. 2018 Mar;14(6s):53-57. doi: 10.2217/fon-2017-0386.
An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker.
由于 Biancavilla 存在恶性间皮瘤 (MM)，其标准化发病率和死亡率有所增加。环境调查显示存在石棉状纤维：氟镁闪石 (FE)。从接触到 MM 潜伏期为 20-60 年，因此迫切需要特定且敏感的生物标志物。为此，我们评估了与 FE 暴露相关的 MM 患者中纤维连接蛋白-3 (Fb-3) 的免疫表达及其预后作用。对居住在 Biancavilla 的 8 名 MM 患者进行了 Fb-3 的免疫组织化学分析，分析结果表明存在暴露于 FE 纤维的环境证据。6 例 MM 病例（3 例上皮样和 3 例双相）显示肿瘤细胞中 Fb-3 的高免疫表达，具有核和细胞质定位。1 例上皮样和 1 例双相亚型未显示 Fb-3 免疫染色。结果表明 Fb-3 与 FE 暴露导致的 MM 有关，可能提示其作为诊断和预后标志物的潜在作用。
