Çakırca Gökhan, Çelik Muhammet Murat
Department of Biochemistry, Şanlıurfa Mehmet Akif Inan Training and Research Hospital, Şanlıurfa, Turkey.
Turk Kardiyol Dern Ars. 2018 Apr;46(3):184-190. doi: 10.5543/tkda.2018.93762.
The aim of this study was to investigate lipid profiles and atherogenic indices and their association with platelet indices in Familial Mediterranean Fever (FMF) patients.
A total of 63 FMF patients and 51 healthy individuals were included in this retrospective study. Inflammatory marker values (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and fibrinogen), platelet indices (mean platelet volume, plateletcrit value, platelet large cell ratio, and platelet distribution width), lipid profiles (levels of total cholesterol, triglycerides, high-density lipoprotein [HDL] cholesterol, and low-density lipoprotein cholesterol) were recorded. Atherogenic indices (atherogenic index of plasma [AIP], atherogenic coefficient [AC], Castelli's risk indices I and II [CRI I and II]) were calculated using lipid parameters.
In FMF patients, while AIP, AC, and CRI I and II values were significantly higher than in the healthy control group, the HDL cholesterol level was significantly lower (all p<0.05). However, no significant difference was determined in terms of the other studied parameters (all p>0.05). In male FMF patients, whereas AIP, AC, and CRI I and II values were significantly higher than in female FMF patients, the platelet count, ESR, and HDL cholesterol levels were significantly lower (all p<0.05). The level of CRP was negatively correlated with HDL cholesterol (r=-0.275; p=0.032) and total cholesterol level (r=-0.313; p=0.014) in FMF patients. HDL cholesterol level was negatively correlated with disease duration (r=-0.269; p=0.049).
The use of atherogenic indices may be recommended to identify patients with an increased risk of atherosclerotic cardiovascular disease in FMF, especially in male patients.
本研究旨在调查家族性地中海热（FMF）患者的血脂谱、致动脉粥样硬化指数及其与血小板指标的关联。
本回顾性研究共纳入63例FMF患者和51名健康个体。记录炎症标志物值（红细胞沉降率[ESR]、C反应蛋白[CRP]和纤维蛋白原）、血小板指标（平均血小板体积、血小板压积值、血小板大细胞比率和血小板分布宽度）、血脂谱（总胆固醇、甘油三酯、高密度脂蛋白[HDL]胆固醇和低密度脂蛋白胆固醇水平）。使用血脂参数计算致动脉粥样硬化指数（血浆致动脉粥样硬化指数[AIP]、致动脉粥样硬化系数[AC]、卡斯泰利风险指数I和II[CRI I和II]）。
在FMF患者中，AIP、AC以及CRI I和II值显著高于健康对照组，而HDL胆固醇水平显著较低（均p<0.05）。然而，在其他研究参数方面未发现显著差异（均p>0.05）。在男性FMF患者中，AIP、AC以及CRI I和II值显著高于女性FMF患者，而血小板计数、ESR和HDL胆固醇水平显著较低（均p<0.05）。FMF患者中CRP水平与HDL胆固醇呈负相关（r=-0.275；p=0.032）以及与总胆固醇水平呈负相关（r=-0.313；p=0.014）。HDL胆固醇水平与疾病持续时间呈负相关（r=-0.269；p=0.049）。
对于识别FMF患者，尤其是男性患者中动脉粥样硬化性心血管疾病风险增加的患者，可能建议使用致动脉粥样硬化指数。
