Department of Internal Medicine, Division of Rheumatology, Health Sciences University Erzurum Regional Education and Research Hospital, Erzurum, Turkey.
Department of Biostatistics, School of Medicine, Ataturk University, Erzurum, Turkey.
Clin Rheumatol. 2022 Nov;41(11):3471-3477. doi: 10.1007/s10067-022-06312-x. Epub 2022 Jul 30.
The plasma atherogenic index (PAI) is associated with cardiovascular diseases. This study evaluated the relationship between PAI and obesity in patients with familial Mediterranean fever (FMF) and its advantage over conventional lipid components in predicting obesity.
The cross-sectional study included 164 FMF patients in the attack-free period and a control group of 160 healthy individuals. Serum lipid components were measured, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). PAI was calculated as log 10 (TG/HDL-C). The relationship between PAI, four conventional lipid profiles, and obesity was evaluated.
The mean PAI values (p = 0.003), frequency of obesity (p = 0.005), TC (p = 0.008), TG (p = 0.000), and LDL-C (p = 0.005) values were determined to be statistically significantly higher in the FMF patients than in the control group. The FMF patients with a higher PAI value had a higher risk of obesity, systolic and diastolic blood pressure, TC, and LDL-C, and lower HDL-C (p < 0.001). The Pearson coefficient for PAI (r = 0.854; p < 0.001) was calculated as an explanatory percentage on the variable of obesity of r = 0.730. There was a stronger relationship between obesity and PAI than conventional lipid components (p < 0.001).
We have found that the PAI, BMI, TC, TG, and LDL-C values of the FMF patients were determined to be higher. The higher PAI was strongly correlated to obesity in FMF patients. The first time in FMF patients, PAI showed increased sensitivity to predict obesity, higher than conventional lipid components. It can be a promising biomarker for obesity compared to other lipid components. A low-cost and readily available index derived from routine (TG and HDL-C) tests are advantages in identifying obesity in FMF patients. Key Points • The PAI is valuable for atherosclerotic CVD risk management in patients with rheumatismal diseases. • A correlation is found between PAI level and obesity, and it is used as a biomarker for obesity in the healthy population. • The PAI revealed increased sensitivity to predict obesity, higher than conventional lipid components in FMF patients.
血浆致动脉粥样硬化指数（PAI）与心血管疾病有关。本研究评估了 PAI 与家族性地中海热（FMF）患者肥胖之间的关系及其在预测肥胖方面优于传统脂质成分的优势。
这项横断面研究纳入了 164 名处于无发作期的 FMF 患者和 160 名健康对照者。测量了血清脂质成分，包括甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。通过计算 log10（TG/HDL-C）得出 PAI。评估了 PAI、四种传统脂质谱与肥胖之间的关系。
FMF 患者的平均 PAI 值（p=0.003）、肥胖发生率（p=0.005）、TC（p=0.008）、TG（p=0.000）和 LDL-C（p=0.005）均高于对照组。PAI 值较高的 FMF 患者肥胖、收缩压和舒张压、TC 和 LDL-C 的风险更高，而 HDL-C 则更低（p<0.001）。PAI 的 Pearson 系数（r=0.854；p<0.001）被计算为解释变量肥胖的 r=0.730 的百分比。肥胖与 PAI 之间的关系强于与传统脂质成分之间的关系（p<0.001）。
我们发现 FMF 患者的 PAI、BMI、TC、TG 和 LDL-C 值较高。在 FMF 患者中，较高的 PAI 与肥胖密切相关。首次在 FMF 患者中发现，PAI 对肥胖的预测敏感性高于传统脂质成分。与其他脂质成分相比，它可能成为肥胖的有前途的生物标志物。从常规（TG 和 HDL-C）检测中获得的低成本且易于获取的指标具有识别 FMF 患者肥胖的优势。
PAI 对风湿性疾病患者的动脉粥样硬化性心血管疾病风险管理具有重要价值。
PAI 水平与肥胖之间存在相关性，可作为健康人群肥胖的生物标志物。
在 FMF 患者中，PAI 对肥胖的预测敏感性高于传统脂质成分，显示出更高的敏感性。
