Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Terry Fox Laboratory British Columbia Cancer Agency, Vancouver, BC, Canada.
Immunol Rev. 2018 May;283(1):41-53. doi: 10.1111/imr.12643.
Immunological memory, traditionally thought to belong to T and B cells, has now been extended to innate lymphocytes, including NK cells and ILC2s, myeloid cells such as macrophages, also termed "trained immunity" and more recently to epithelial stem cells. In this review, we discuss the mechanisms underlying memory generation on ILC2s and speculate about their potential role in human allergic diseases, such as asthma. Moreover, we examine the relevance of the spontaneous ILC2 activation in the lung during the neonatal period in order to efficiently respond to stimuli later in life. These "training" of neonatal ILC2s may have an impact on the generation of memory ILC2s in the adulthood.
免疫记忆，传统上被认为属于 T 细胞和 B 细胞，现在已经扩展到先天淋巴细胞，包括 NK 细胞和 ILC2 细胞、髓样细胞如巨噬细胞，也称为“训练免疫”，最近还扩展到上皮干细胞。在这篇综述中，我们讨论了 ILC2 上记忆产生的机制，并推测它们在人类过敏性疾病（如哮喘）中的潜在作用。此外，我们研究了在新生儿期肺内自发的 ILC2 激活的相关性，以便在以后的生活中有效地对刺激作出反应。这些“训练”新生儿 ILC2 可能会对成年期记忆性 ILC2 的产生产生影响。
