β-氨基芳基酮的脱氢环化反应电化学合成三取代 2-恶唑啉。
Electrosynthesis of Trisubstituted 2-Oxazolines via Dehydrogenative Cyclization of β-Amino Arylketones.
机构信息
Engineering Technology Research Center of Henan Province for Solar Catalysis, College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , Henan 473061 , P. R. China.
Department of Organic Chemistry, Faculty of Science , Beijing University of Chemical Technology , Beijing 100029 , China.
出版信息
Org Lett. 2018 May 4;20(9):2505-2508. doi: 10.1021/acs.orglett.8b00165. Epub 2018 Apr 17.
An electrochemically intramolecular functionalization of C(sp)-H bonds with masked oxygen nucleophiles was developed. With KI as the catalyst and electrolyte, diverse trisubstituted 2-oxazolines were constructed in good to excellent yields. This newly developed electrochemical dehydrogenative approach features external oxidant-free and additive-free conditions.
开发了一种电化学分子内 C(sp)-H 键与掩蔽氧亲核试剂的功能化方法。以 KI 作为催化剂和电解质，在良好到优秀的收率下构建了多种三取代 2-噁唑啉。这种新开发的电化学脱氢方法具有无外加氧化剂和添加剂的特点。
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