Yang Q T, Wu K S, Li Z J, Li W C, Lu L, Wu H Q, Zhuang Y Y, Sui X X
Department of Preventive Medicine, Shantou University Medical College, Shantou, China.
Department of Urology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Andrologia. 2018 Aug;50(6):e13016. doi: 10.1111/and.13016. Epub 2018 Apr 17.
The European Male Aging Study (EMAS) has recently defined strict diagnostic criteria for late-onset hypogonadism (LOH) including the levels of serum total testosterone (TT), free testosterone (FT) and three sexual symptoms. However, there is no report on risk factors for LOH using these criteria. In this study, we investigated risk factors for LOH based on these criteria. We recruited 277 men (aged 36-80 years) who completed both a health check-up and two questionnaires (a health and lifestyle questionnaire, and a sexual function questionnaire). Data on parameters, such as systolic blood pressure (SBP), glucose, triglyceride (TG) and high-density lipoprotein (HDL), were obtained from medical records of the hospital in Shantou. TT and sex hormone-binding globulin (SHBG) were measured by chemiluminescent immunoassay, and FT was calculated. TT, FT, age, waist circumference, SBP and glucose showed significant differences between LOH-positive and LOH-negative individuals. Univariate regression analyses showed that age, waist circumference, SBP, glucose and health status were risk factors for LOH. Pearson's correlation analysis revealed that TT was inversely correlated with waist circumference, glucose and SBP, and FT was inversely correlated with age, SBP and health status. In conclusion, age, waist circumference, SBP, glucose and health status were risk factors for LOH.
欧洲男性衰老研究（EMAS）最近为迟发性性腺功能减退（LOH）定义了严格的诊断标准，包括血清总睾酮（TT）、游离睾酮（FT）水平以及三种性症状。然而，尚无使用这些标准对LOH危险因素进行报告的研究。在本研究中，我们基于这些标准调查了LOH的危险因素。我们招募了277名年龄在36 - 80岁之间的男性，他们均完成了健康检查以及两份问卷（一份健康与生活方式问卷和一份性功能问卷）。收缩压（SBP）、血糖、甘油三酯（TG）和高密度脂蛋白（HDL）等参数的数据来自汕头某医院的病历记录。TT和性激素结合球蛋白（SHBG）通过化学发光免疫分析法进行测定，FT则通过计算得出。LOH阳性和阴性个体之间的TT、FT、年龄、腰围、SBP和血糖存在显著差异。单因素回归分析表明，年龄、腰围、SBP、血糖和健康状况是LOH的危险因素。Pearson相关性分析显示，TT与腰围、血糖和SBP呈负相关，FT与年龄、SBP和健康状况呈负相关。总之，年龄、腰围、SBP、血糖和健康状况是LOH的危险因素。
