Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Chem Rec. 2018 Oct;18(10):1474-1488. doi: 10.1002/tcr.201800005. Epub 2018 Apr 17.
The chemistry of hydrogen cyanide adducts of imines is well-developed, but that of cyanide adducts remains unexplored. This is presumably because these cyanide adducts are not stable and thus not readily available in their isolated forms. In this personal account, we present the progress made in our research program towards the development of novel organic transformations utilizing cyanide adducts of imines as key intermediates. We also report the application of these methodologies to the total synthesis of natural products including indole alkaloids.
亚胺的氢氰酸加合物的化学性质已经得到了很好的发展，但氰化物加合物的化学性质仍未得到探索。这大概是因为这些氰化物加合物不稳定，因此不易以其分离形式获得。在这篇个人报告中，我们介绍了我们在利用亚胺的氰化物加合物作为关键中间体开发新型有机转化方面的研究计划所取得的进展。我们还报告了这些方法在包括吲哚生物碱在内的天然产物全合成中的应用。
