Loesch A, Lincoln J, Burnstock G
Department of Anatomy and Developmental Biology, University College London, Great Britain.
Acta Neuropathol. 1988;75(4):391-401. doi: 10.1007/BF00687793.
The hypothalamic paraventricular and supraoptic nuclei and the neurohypophysis of rats were investigated 8 weeks after streptozotocin (STZ)-induction of type 1 diabetes. Vasopressin (VP)- and oxytocin (OT)-containing neuronal profiles were examined using the pre-embedding peroxidase-antiperoxidase technique for electron microscopy. Ultrastructural alterations were observed in the somata, dendrites and axons of VP- and OT-labelled profiles. There was no evidence, however, for alterations in the synapses associated with VP- or OT-labelled somata, dendrites and axons. The results indicate that both VP- and OT-containing neuronal profiles are involved in the ultrastructural reorganisation of the hypothalamo-neurohypophysial complex during diabetic conditions. Depletion of VP- and OT-containing axon profiles in the neurohypophysis may suggest increased release of both neurohypophysial hormones in STZ-induced diabetes.
在链脲佐菌素（STZ）诱导1型糖尿病8周后，对大鼠的下丘脑室旁核和视上核以及神经垂体进行了研究。采用包埋前过氧化物酶-抗过氧化物酶技术进行电子显微镜检查，以检测含血管加压素（VP）和催产素（OT）的神经元形态。在VP和OT标记的形态的胞体、树突和轴突中观察到超微结构改变。然而，没有证据表明与VP或OT标记的胞体、树突和轴突相关的突触有改变。结果表明，在糖尿病状态下，含VP和OT的神经元形态均参与下丘脑-神经垂体复合体的超微结构重组。神经垂体中含VP和OT的轴突形态减少可能提示在STZ诱导的糖尿病中两种神经垂体激素的释放增加。
