Ciosek J, Cisowska A
Department of Pathophysiology, Medical University of Lodz, Poland.
J Physiol Pharmacol. 2003 Dec;54(4):625-41.
Galanin (Gal) as a neuropeptide with widespread distribution in the central nervous system may be involved in the mechanisms of vasopressin (AVP) and oxytocin (OT) release from the hypothalamo-neurohypophysial system. Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats. In not dehydrated rats intracerebroventricular (i.c.v.) injections of Gal did not affect the hypothalamic and neurohypophysial OT content, however, distinctly increased plasma OT concentration. In the same animals Gal diminished the hypothalamic AVP content but was without the effect on neurohypophysial AVP storage; plasma AVP level then raised. Galanin, administered i.c.v. to rats deprived of water, distinctly inhibited AVP and OT release from the hypothalamo-neurohypophysial system. Simultaneously, plasma AVP and OT level was significantly diminished after Gal treatment in dehydrated rats. These results suggest that modulatory effect of galanin on vasopressin and oxytocin release depends on the actual state of water metabolism. Gal acts as an inhibitory neuromodulator of AVP and OT secretion under conditions of the dehydration but stimulates this process in the state of equilibrated water metabolism.
甘丙肽（Gal）作为一种在中枢神经系统广泛分布的神经肽，可能参与下丘脑 - 神经垂体系统中血管加压素（AVP）和催产素（OT）释放的机制。在给正常水合和脱水大鼠注射甘丙肽后，研究了下丘脑和神经垂体中血管加压素和催产素的含量以及这两种神经激素的血浆水平。在未脱水的大鼠中，脑室内（i.c.v.）注射甘丙肽不影响下丘脑和神经垂体中催产素的含量，但明显增加血浆催产素浓度。在同一批动物中，甘丙肽降低了下丘脑血管加压素的含量，但对神经垂体中血管加压素的储存没有影响；随后血浆血管加压素水平升高。给缺水大鼠脑室内注射甘丙肽，明显抑制下丘脑 - 神经垂体系统中血管加压素和催产素的释放。同时，在脱水大鼠中注射甘丙肽后，血浆血管加压素和催产素水平显著降低。这些结果表明，甘丙肽对血管加压素和催产素释放的调节作用取决于水代谢的实际状态。在脱水状态下，甘丙肽作为血管加压素和催产素分泌的抑制性神经调节剂，但在水代谢平衡状态下刺激这一过程。
