Ribot C, Tremollieres F, Pouilles J M, Bonneu M, Germain F, Louvet J P
Unité des Maladies Osseuses et Métaboliques, Service d'Endocrinologie-CHU Toulouse Purpan, Toulouse, France.
Bone. 1987;8(6):327-31. doi: 10.1016/8756-3282(87)90062-7.
This study was undertaken to evaluate the effect of obesity on the postmenopausal bone mass. Bone mineral density, measured by dual photon absorptiometry of the lumbar spine, serum osteocalcin (OC), fasting urinary calcium to creatinine (Ca:Cr), serum estradiol (E2) dehydroepiandrosterone (DHA) and testosterone (T) were measured in 176 women aged 45-71 years. Women were divided into four groups according to their menopausal status and their weight: 49 perimenopausal, 28 obese perimenopausal, 49 obese postmenopausal. Within each population (perimenopausal and postmenopausal), mean age was the same, only weight was significantly different (p less than 0.0001). For the two groups of postmenopausal women mean interval since menopause (YSM) was the same (5.8 +/- 3 and 5.4 +/- 5 yr). Comparison between groups revealed a significant effect of menopausal status and obesity on BMD and bone turnover. As compared to perimenopausal women, BMD was lower, OC and Ca: Cr higher only in nonobese-postmenopausal women. E2, T, DHA did not differ between the two groups of postmenopausal women. The results of this study suggest that even moderate obesity can play a protective role on postmenopausal bone loss.
本研究旨在评估肥胖对绝经后骨量的影响。对176名年龄在45 - 71岁的女性测量了腰椎双能光子吸收法测定的骨矿物质密度、血清骨钙素（OC）、空腹尿钙肌酐比（Ca:Cr）、血清雌二醇（E2）、脱氢表雄酮（DHA）和睾酮（T）。根据绝经状态和体重将女性分为四组：49名围绝经期女性、28名肥胖围绝经期女性、49名肥胖绝经后女性。在每组人群（围绝经期和绝经后）中，平均年龄相同，仅体重有显著差异（p < 0.0001）。两组绝经后女性的平均绝经间隔时间（YSM）相同（5.8 ± 3年和5.4 ± 5年）。组间比较显示绝经状态和肥胖对骨密度和骨转换有显著影响。与围绝经期女性相比，仅在非肥胖绝经后女性中骨密度较低，OC和Ca:Cr较高。两组绝经后女性的E2、T、DHA无差异。本研究结果表明，即使是中度肥胖也可对绝经后骨质流失起到保护作用。
