College of Pharmacy, Jilin Medical University, Jilin, 132013, China.
Org Biomol Chem. 2018 May 2;16(17):3282-3288. doi: 10.1039/c8ob00305j.
The development of a method for the Pd(ii)-catalyzed denitrogenative coupling of arylhydrazines to give functionalized biaryls in good yield, using aryl bromides or aryl iodides as convenient and inexpensive aryl sources, is reported. High functional group tolerance is demonstrated for electronically distinct arylhydrazines as well as aryl halides. The desired products were isolated in good to excellent yields for 58 examples. Control experiments and mechanism studies revealed that the transformation undergoes a base-promoted Pd-catalyzed process.
本文报道了一种钯（II）催化的芳基腙与芳基溴或芳基碘的脱氮偶联方法，该方法可以高产率得到功能化联芳烃。该方法使用芳基溴或芳基碘作为方便且廉价的芳基源，具有高的官能团容忍性，对电子不同的芳基腙和芳基卤化物都适用。58 个实例的产物收率良好至优秀。控制实验和机理研究表明，该转化经历了碱促进的钯催化过程。
