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FeO(OH)@C 催化的对硝基芳基氟化物的选择性肼取代及其在酞嗪酮合成中的应用。

FeO(OH)@C-Catalyzed Selective Hydrazine Substitution of p-Nitro-Aryl Fluorides and their Application for the Synthesis of Phthalazinones.

机构信息

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.

Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Lab of Optoelectronics Devices and systems of Ministry of Education/Guangdong Province, Shenzhen University, Shenzhen, 518060, P. R. China.

出版信息

ChemistryOpen. 2022 May;11(5):e202200023. doi: 10.1002/open.202200023.

DOI:10.1002/open.202200023
PMID:35585033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9117154/
Abstract

An efficient hydrazine substitution of p-nitro-aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p-nitro-aryl fluorides bearing electron-withdrawing groups proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p-nitro-aryl fluorides containing electron-donating groups also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines, some phthalazinones, interesting as potential structures for pharmaceuticals, have successfully been synthesized in high yields.

摘要

FeO(OH)@C 纳米粒子催化水合肼高效取代对硝基芳基氟化物。该方法对含有吸电子基团的对硝基芳基氟化物的肼取代反应具有高效、高选择性。类似地，含有供电子基团的对硝基芳基氟化物的氢化反应也能在温和条件下顺利进行。此外，利用这些制备得到的芳基肼，成功地以高产率合成了一些酞嗪酮，它们具有作为潜在药物结构的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/654944e07f91/OPEN-11-e202200023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/87b199de3b99/OPEN-11-e202200023-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/fb3664de34d3/OPEN-11-e202200023-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/d5f88643cc44/OPEN-11-e202200023-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/4f4a7bf6ef40/OPEN-11-e202200023-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/176662525491/OPEN-11-e202200023-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/654944e07f91/OPEN-11-e202200023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/87b199de3b99/OPEN-11-e202200023-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/fb3664de34d3/OPEN-11-e202200023-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/d5f88643cc44/OPEN-11-e202200023-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/4cde3dabe13b/OPEN-11-e202200023-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/4f4a7bf6ef40/OPEN-11-e202200023-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/176662525491/OPEN-11-e202200023-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d095/9117154/654944e07f91/OPEN-11-e202200023-g001.jpg

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