Kumar N, Khakoo S I
Section of Hepatology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Department of Clinical and Experimental Sciences, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK.
HLA. 2018 Apr 17. doi: 10.1111/tan.13275.
Liver disease is a growing cause of death in the United Kingdom and the incidence of hepatocellular carcinoma (HCC) is rising (http://www.cancerresearchuk.org/). The combination of an immunosuppressive environment within the liver and suboptimal host anti-tumour immune responses may account for the poor survival outcome of HCC. Understanding how tumours evade immune recognition coupled with new insights into the unique immunological environment within the liver will be critical to developing liver-specific immunotherapies.
在英国，肝病正成为一个日益严重的死亡原因，肝细胞癌（HCC）的发病率也在上升（http://www.cancerresearchuk.org/）。肝脏内免疫抑制环境与宿主抗肿瘤免疫反应欠佳相结合，可能是导致HCC患者生存结局不佳的原因。了解肿瘤如何逃避免疫识别，以及对肝脏内独特免疫环境的新认识，对于开发肝脏特异性免疫疗法至关重要。
