Juengpanich Sarun, Shi Liang, Iranmanesh Yasaman, Chen Jiang, Cheng Zhenzhe, Khoo Aaron Kah-Jin, Pan Long, Wang Yifan, Cai Xiujun
Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang, Province, China; School of Medicine, Zhejiang University, Hangzhou 310058, China.
Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang, Province, China.
Transl Oncol. 2019 Aug;12(8):1092-1107. doi: 10.1016/j.tranon.2019.04.021. Epub 2019 Jun 6.
A major obstacle for treatment of HCC is the inadequate efficacy and limitation of the available therapeutic options. Despite the recent advances in developing novel treatment options, HCC still remains one of the major causes of cancer morbidity and mortality around the world. Achieving effective treatment and eradication of HCC is a challenging task, however recent studies have shown that targeting Natural Killer cells, as major regulators of immune system, can help with the complete treatment of HCC, restoration of normal liver function and subsequently higher survival rate of HCC patients. Studies have shown that decrease in the frequency of NK cells, their dysfunction due to several factors such as dysregulation of receptors and their ligands, and imbalance of different types of inhibitory and stimulating microRNA expression is associated with higher rate of HCC progression and development, and poor survival outcome. Here in our review, we mainly focused on the importance of NK cells in HCC development and treatment.
肝癌治疗的一个主要障碍是现有治疗方案的疗效不足和局限性。尽管在开发新型治疗方案方面取得了最新进展，但肝癌仍然是全球癌症发病率和死亡率的主要原因之一。实现肝癌的有效治疗和根除是一项具有挑战性的任务，然而最近的研究表明，作为免疫系统主要调节因子的自然杀伤细胞（Natural Killer cells），可以帮助实现肝癌的彻底治疗、恢复正常肝功能，并随后提高肝癌患者的生存率。研究表明，自然杀伤细胞数量减少、由于受体及其配体失调等多种因素导致的功能障碍，以及不同类型抑制性和刺激性微小RNA表达失衡，都与肝癌的更高进展和发展速度以及不良生存结果相关。在本综述中，我们主要关注自然杀伤细胞在肝癌发生和治疗中的重要性。
